Basic Information
| Drug ID | DDPD01022 |
|
| Drug Name | Phylloquinone | |
| Molecular Weight | 450.6957 | |
| Molecular Formula | C31H46O2 | |
| CAS Number | 84-80-0 | |
| SMILES | CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC\C(C)=C\CC1=C(C)C(=O)C2=C(C=CC=C2)C1=O | |
| External Links | ||
| DRUGBANK | DB01022 | |
| T3DB | T3D2959 | |
| PubChem Compound | 5284607 | |
| PDR | 2157 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 9.3 | - | 9.3 | - | DRUGBANK |
| Boiling Point | 142.5 | ℃ | 142.5 | ℃ | PhysProp |
| Melting Point | -20.0 | ℃ | -20 | ℃ | PhysProp |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Clearance | 0.0960 | L/h/kg | 1.6 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 0.32 | L/kg | 0.32 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 7.3 | h | 7.3 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Toxicity LD50 | 41.5 | ml/kg | 41.5 | mL/kg | intravenous injection, IV; mouse; | DRUGBANK | Toxicity LD50 | 52.0 | ml/kg | 52.0 | mL/kg | intravenous injection, IV; mouse; | DRUGBANK | Toxicity LD50 | 41.5 | ml/kg | 41.5 | mL/kg | intravenous injection, IV; mouse; | T3DB | Toxicity LD50 | 52.0 | ml/kg | 52.0 | mL/kg | intravenous injection, IV; mouse; | T3DB |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for neonates | 10.0 | mg/day/dose | 10 | mg/day/dose | PO, oral;intravenous injection, IV;IM,intramuscular injection;subcutaneous injection, SC; | Mephyton | phytonadione | PDR |
| Max dose for infants | 10.0 | mg/day/dose | 10 | mg/day/dose | PO, oral;intravenous injection, IV;IM,intramuscular injection;subcutaneous injection, SC; | Mephyton | phytonadione | PDR |
| Max dose for children | 10.0 | mg/day/dose | 10 | mg/day/dose | PO, oral;intravenous injection, IV;IM,intramuscular injection;subcutaneous injection, SC; | Mephyton | phytonadione | PDR |
| Max dose for adolescents | 10.0 | mg/dose/day | 10 | mg/day/dose | PO, oral;intravenous injection, IV;IM,intramuscular injection;subcutaneous injection, SC; | Mephyton | phytonadione | PDR |
| Max dose for geriatric | 10.0 | mg/day/dose | 10 | mg/day/dose | PO, oral;intravenous injection, IV;IM,intramuscular injection;subcutaneous injection, SC; | Mephyton | phytonadione | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1