Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD01020 ...
Drug Name Isosorbide mononitrate
Molecular Weight 191.1388
Molecular Formula C6H9NO6
CAS Number 16051-77-7
SMILES [H][C@]12OC[C@@H](O[N+]([O-])=O)[C@@]1([H])OC[C@@H]2O
External Links
DRUGBANK DB01020
PubChem Compound 27661
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P -0.15 - -0.15 - SANGSTER (1993)

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
Absorption 100.0 % 100 % PO, oral; DRUGBANK
Bioavailability 93.0 % 93±13 % PO, oral; The Pharmacological Basis of Therapeutics
C Max 230.0 ng/ml 314-2093 nM PO, oral; The Pharmacological Basis of Therapeutics
T Max 0.75 h 0.5-1 h PO, oral; DRUGBANK
T Max 1.3 h 1-1.5 h PO, oral; The Pharmacological Basis of Therapeutics
Clearance 7.1 L/h 115-120 ml/min Total clearance; DRUGBANK
Clearance 0.11 L/h/kg 1.80±0.24 ml/min/kg Elderly → ;Hepatic cirrhosis, cirr → ;RD, renal impairment, Renal disease，including uremia → ;coronary artery disease → ; The Pharmacological Basis of Therapeutics
Volume of Distribution 0.60 L/kg ~0.6 L/kg DRUGBANK
Volume of Distribution 0.73 L/kg 0.73±0.09 L/kg Elderly → ;Hepatic cirrhosis, cirr → ;RD, renal impairment, Renal disease，including uremia → ;coronary artery disease → ;myocardial infarction → ; The Pharmacological Basis of Therapeutics
Half-life 5.0 h ~5 h elimination half-life; DRUGBANK
Half-life 6.0 h 6 h elimination half-life; DRUGBANK
Half-life 8.0 h 8 h elimination half-life; DRUGBANK
Half-life 4.9 h 4.9±0.8 h Hepatic cirrhosis, cirr → ;RD, renal impairment, Renal disease，including uremia → ;myocardial infarction → ;coronary artery disease → ;Age → ; The Pharmacological Basis of Therapeutics
Toxicity LD50 2010.0 mg/kg 2010.0 mg/kg PO, oral; Rattus, Rat; DRUGBANK
Toxicity LD50 1771.0 mg/kg 1771.0 mg/kg PO, oral; mouse; DRUGBANK
Eliminate Route 48.0 % ~48 % Urinary excretion; DRUGBANK
Eliminate Route 2.0 % 2 % Urinary excretion; PO, oral; Unchanged drug; DRUGBANK
Eliminate Route 5.0 % <5 % Urinary excretion; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 5.0 % ~5 % DRUGBANK
Protein Binding 0 % 0 % The Pharmacological Basis of Therapeutics

Maximum Dosage

Not Available

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1