Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD01017 ...
Drug Name Minocycline
Molecular Weight 457.4764
Molecular Formula C23H27N3O7
CAS Number 10118-90-8
SMILES [H][C@@]12CC3=C(C(O)=CC=C3N(C)C)C(=O)C1=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@@H](N(C)C)[C@]1([H])C2
External Links
DRUGBANK DB01017
PubChem Compound 54675783
PDR 1352
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 0.05 - 0.05 - SANGSTER (1993)
Boiling Point 753.2 ℃ 753.2 ℃ ChemSpider
Water Solubility 52000.0 mg/L 52000 mg/L YALKOWSKY,SH & DANNENFELSER,RM 1992)

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
AUC 31600.0 ng.h/ml 31.6 mg.h/l PO, oral; DRUGBANK
AUC 48300.0 ng.h/ml 48.3 mg.h/l PO, oral; DRUGBANK
C Max 1600.0 ng/ml 1.6±0.9 mg/L PO, oral; DRUGBANK
C Max 3100.0 ng/ml 3.1 mg/L PO, oral; DRUGBANK
T Max 1.9 h 1.9 h PO, oral; DRUGBANK
T Max 2.5 h 2.5 h PO, oral; DRUGBANK
Clearance 4.5 L/h 3.36-5.7 L/h intravenous injection, IV; DRUGBANK
Clearance 3.9 L/h 3.42-4.4 L/h PO, oral; DRUGBANK
Clearance 0.0720 L/h/kg 1.2 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 91.3 L 67.5-115 L DRUGBANK
Volume of Distribution 1.6 L/kg 1.6 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 16.6 h 11.1-22.1 h Capsule, PO, Oral; DRUGBANK
Half-life 19.0 h 15-23 h intravenous injection, IV; DRUGBANK
Half-life 17.0 h 17 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Toxicity LD50 2380.0 mg/kg 2380.0 mg/kg PO, oral; Rattus, Rat; DRUGBANK
Toxicity LD50 3600.0 mg/kg 3600.0 mg/kg PO, oral; mouse; DRUGBANK
Toxicity LD50 331.0 mg/kg 331.0 mg/kg Intraperitoneal, IP; Rattus, Rat; DRUGBANK
Toxicity LD50 299.0 mg/kg 299.0 mg/kg Intraperitoneal, IP; mouse; DRUGBANK
Toxicity LD50 1700.0 mg/kg 1700.0 mg/kg subcutaneous injection, SC; Rattus, Rat; DRUGBANK
Toxicity LD50 2290.0 mg/kg 2290.0 mg/kg subcutaneous injection, SC; mouse; DRUGBANK
Eliminate Route 6.8 % 4.5-9 % Urinary excretion; intravenous injection, IV; DRUGBANK
Eliminate Route 14.8 % 10-19.5 % Urinary excretion; PO, oral; DRUGBANK
Eliminate Route 27.0 % 20-34 % Faeces excretion; PO, oral; DRUGBANK
Protein Binding 76.0 % 76 % DRUGBANK

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for children 4.0 mg/kg/day 4 mg/kg/day intravenous injection, IV; day1 Arestin minocycline hydrochloride PDR
Max dose for children 300.0 mg 300 mg intravenous injection, IV; day1 Arestin minocycline hydrochloride PDR
Max dose for children 200.0 mg/day 200 mg/day intravenous injection, IV Arestin minocycline hydrochloride PDR
Max dose for children 4.0 mg/kg/day 4 mg/kg/day PO, oral; day1 Arestin minocycline hydrochloride PDR
Max dose for children 300.0 mg 300 mg PO, oral; day1 Arestin minocycline hydrochloride PDR
Max dose for children 200.0 mg/day 200 mg/day PO, oral Arestin minocycline hydrochloride PDR
Max dose for children 1.0 mg/kg/day 1 mg/kg/day PO, oral Arestin minocycline hydrochloride PDR
Max dose for children 135.0 mg/day 135 mg/day PO, oral Arestin minocycline hydrochloride PDR
Max dose for children 1.0 application/day 1 application/day skin,foam Arestin minocycline hydrochloride PDR
Max dose for children 4.0 mg/kg/day 4 mg/kg/day intravenous injection, IV; day1 Arestin minocycline hydrochloride PDR
Max dose for children 300.0 mg 300 mg intravenous injection, IV; day1 Arestin minocycline hydrochloride PDR
Max dose for children 200.0 mg/day 200 mg/day intravenous injection, IV Arestin minocycline hydrochloride PDR
Max dose for children 4.0 mg/kg/day 4 mg/kg/day PO, oral; day1 Arestin minocycline hydrochloride PDR
Max dose for children 300.0 mg 300 mg PO, oral; day1 Arestin minocycline hydrochloride PDR
Max dose for children 200.0 mg/day 200 mg/day PO, oral Arestin minocycline hydrochloride PDR
Max dose for children 1.0 application/day 1 application/day skin,foam Arestin minocycline hydrochloride PDR
Max dose for children 4.0 mg/kg/day 4 mg/kg/day intravenous injection, IV; day1 Arestin minocycline hydrochloride PDR
Max dose for children 300.0 mg 300 mg intravenous injection, IV; day1 Arestin minocycline hydrochloride PDR
Max dose for children 200.0 mg/day 200 mg/day intravenous injection, IV Arestin minocycline hydrochloride PDR
Max dose for children 4.0 mg/kg/day 4 mg/kg/day PO, oral; day1 Arestin minocycline hydrochloride PDR
Max dose for children 300.0 mg 300 mg PO, oral; day1 Arestin minocycline hydrochloride PDR
Max dose for children 200.0 mg/day 200 mg/day PO, oral Arestin minocycline hydrochloride PDR
Max dose for adolescents 4.0 mg/kg/day 4 mg/kg/day intravenous injection, IV; day1 Arestin minocycline hydrochloride PDR
Max dose for adolescents 300.0 mg 300 mg intravenous injection, IV; day1 Arestin minocycline hydrochloride PDR
Max dose for adolescents 200.0 mg/day 200 mg/day intravenous injection, IV Arestin minocycline hydrochloride PDR
Max dose for adolescents 4.0 mg/kg/day 4 mg/kg/day PO, oral; day1 Arestin minocycline hydrochloride PDR
Max dose for adolescents 300.0 mg 300 mg PO, oral; day1 Arestin minocycline hydrochloride PDR
Max dose for adolescents 200.0 mg/day 200 mg/day PO, oral Arestin minocycline hydrochloride PDR
Max dose for adolescents 1.0 mg/kg/day 1 mg/kg/day PO, oral Arestin minocycline hydrochloride PDR
Max dose for adolescents 135.0 mg/day 135 mg/day PO, oral Arestin minocycline hydrochloride PDR
Max dose for adolescents 1.0 application/day 1 application/day skin,foam Arestin minocycline hydrochloride PDR
Max dose for adults 400.0 mg/day 400 mg/day intravenous injection, IV Arestin minocycline hydrochloride PDR
Max dose for adults 300.0 mg 300 mg PO, oral; day1 Arestin minocycline hydrochloride PDR
Max dose for adults 200.0 mg/day 200 mg/day PO, oral Arestin minocycline hydrochloride PDR
Max dose for adults 1.0 mg/kg/day 1 mg/kg/day PO, oral Arestin minocycline hydrochloride PDR
Max dose for adults 135.0 mg/day 135 mg/day PO, oral Arestin minocycline hydrochloride PDR
Max dose for adults 122.0 unit-dose cartridges 122 unit-dose cartridges Arestin minocycline hydrochloride PDR
Max dose for adults 1.0 appLication/day 1 appLication/day skin,foam Arestin minocycline hydrochloride PDR
Max dose for geriatric 400.0 mg/day 400 mg/day intravenous injection, IV Arestin minocycline hydrochloride PDR
Max dose for geriatric 300.0 mg 300 mg PO, oral; day1 Arestin minocycline hydrochloride PDR
Max dose for geriatric 200.0 mg/day 200 mg/day PO, oral Arestin minocycline hydrochloride PDR
Max dose for geriatric 1.0 mg/kg/day 1 mg/kg/day PO, oral Arestin minocycline hydrochloride PDR
Max dose for geriatric 135.0 mg/day 135 mg/day PO, oral Arestin minocycline hydrochloride PDR
Max dose for geriatric 122.0 unit-dose cartridges 122 unit-dose cartridges Arestin minocycline hydrochloride PDR
Max dose for geriatric 1.0 application/day 1 application/day skin,foam Arestin minocycline hydrochloride PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1