Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD01016 ...
Drug Name Glyburide
Molecular Weight 494.004
Molecular Formula C23H28ClN3O5S
CAS Number 10238-21-8
SMILES COC1=C(C=C(Cl)C=C1)C(=O)NCCC1=CC=C(C=C1)S(=O)(=O)NC(=O)NC1CCCCC1
External Links
DRUGBANK DB01016
PubChem Compound 3488
PDR 1903

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 3.754 - 3.754 - http://www.chemspider.com/Chemical-Structure.3368.html
Melting Point 169.0 ℃ 169 ℃ PhysProp

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
AUC 348.0 ng.h/ml 348.0 ng.h/ml PO, oral; patients; DRUGBANK
Bioavailability 95.0 % 90-100 % Tablet, PO, oral; Drug form; The Pharmacological Basis of Therapeutics
Bioavailability 77.0 % 64-90 % Tablet, PO, oral; Drug form; The Pharmacological Basis of Therapeutics
C Max 263.0 ng/ml 211-315 ng/ml PO, oral; Geriatric; DRUGBANK
C Max 223.0 ng/ml 144-302 ng/ml PO, oral; adults; patients; DRUGBANK
C Max 106.0 ng/ml 106.0 ng/ml Tablet, PO, oral; Drug form; adults; normal,healthy; The Pharmacological Basis of Therapeutics
C Max 104.0 ng/ml 104.0 ng/ml Tablet, PO, oral; Drug form; adults; normal,healthy; The Pharmacological Basis of Therapeutics
T Max 0.95 h 0.9-1 h PO, oral; Geriatric; DRUGBANK
T Max 2.2 h 1.3-3 h PO, oral; adults; patients; DRUGBANK
T Max 1.5 h ~1.5 h Tablet, PO, oral; Drug form; adults; normal,healthy; The Pharmacological Basis of Therapeutics
T Max 3.0 h 2-4 h Tablet, PO, oral; Drug form; adults; normal,healthy; The Pharmacological Basis of Therapeutics
Clearance 3.1 L/h 2.70-3.55 L/h Geriatric; DRUGBANK
Clearance 3.3 L/h 2.47-4.11 L/h young; patients; DRUGBANK
Clearance 0.0780 L/h/kg 1.3±0.5 ml/min/kg Hepatic cirrhosis, cirr ↓ ; The Pharmacological Basis of Therapeutics
Clearance 0.0492 L/h/kg 0.82 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 36.0 L 19.3-52.6 L Geriatric; DRUGBANK
Volume of Distribution 35.4 L 21.5-49.3 L young; patients; DRUGBANK
Volume of Distribution 0.20 L/kg 0.20±0.11 L/kg The Pharmacological Basis of Therapeutics
Volume of Distribution 0.0800 L/kg 0.08 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 8.7 h 4.0-13.4 h elimination half-life; Geriatric; DRUGBANK
Half-life 9.0 h 4.0-13.9 h elimination half-life; young; patients; DRUGBANK
Half-life 4.0 h 4±1 h Hepatic cirrhosis, cirr ↑ ;non-insulin-dependent diabetes mellitus NIDDM ↑ ; The Pharmacological Basis of Therapeutics
Half-life 8.0 h 6-10 h nonmicronized formulation; The Pharmacological Basis of Therapeutics
Half-life 15.0 h 15 h terminal half-life; The Pharmacological Basis of Therapeutics
Half-life 2.2 h 2.2 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Toxicity LD50 3200.0 mg/kg >3200 mg/kg PO, oral; Rattus, Rat; DRUGBANK
Toxicity LD50 1500.0 mg/kg >1500 mg/kg PO, oral; mouse; DRUGBANK
Toxicity LD50 10000.0 mg/kg >10000 mg/kg PO, oral; rabbit; DRUGBANK
Toxicity LD50 1500.0 mg/kg >1500 mg/kg PO, oral; guinea pigs; DRUGBANK
Eliminate Route 50.0 % 50 % Urinary excretion; DRUGBANK
Eliminate Route 50.0 % 50 % Faeces excretion; DRUGBANK
Eliminate Route 0 % ~0 % Urinary excretion; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 99.9 % 99.9 % plasma proteins; DRUGBANK
Protein Binding 98.0 % >98 % DRUGBANK
Protein Binding 99.8 % 99.8 % Elderly ↓ ; The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for children 10.0 mg/day 10 mg/day PO, oral DiaBeta glyburide PDR
Max dose for adolescents 10.0 mg/day 10 mg/day PO, oral DiaBeta glyburide PDR
Max dose for adults 20.0 mg/day 20 mg/day PO, oral DiaBeta glyburide PDR
Max dose for adults 12.0 mg/day 12 mg/day PO, oral DiaBeta glyburide PDR
Max dose for geriatric 20.0 mg/day 20 mg/day PO, oral DiaBeta glyburide PDR
Max dose for geriatric 12.0 mg/day 12 mg/day PO, oral DiaBeta glyburide PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1