Basic Information
| Drug ID | DDPD01012 |
|
| Drug Name | Cinacalcet | |
| Molecular Weight | 357.412 | |
| Molecular Formula | C22H22F3N | |
| CAS Number | 226256-56-0 | |
| SMILES | C[C@@H](NCCCC1=CC(=CC=C1)C(F)(F)F)C1=CC=CC2=CC=CC=C12 | |
| External Links | ||
| DRUGBANK | DB01012 | |
| PubChem Compound | 156419 | |
| PDR | 2231 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 6.5 | - | 6.5 | - | DRUGBANK |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Factor | Reference |
|---|---|---|---|---|---|---|---|
| Bioavailability | 20.0 | % | ~20 | % | PO, oral; | The Pharmacological Basis of Therapeutics | |
| C Max | 10.6 | ng/ml | 10.6±2.8 | ng/ml | Oral single dose; | The Pharmacological Basis of Therapeutics | |
| T Max | 4.0 | h | 2-6 | h | The Pharmacological Basis of Therapeutics | ||
| Clearance | 1.1 | L/h/kg | ~18 | ml/min/kg | hydrolysis; hydrolysis; hydrolysis; | hepatopathy，LD ↓ ; | The Pharmacological Basis of Therapeutics |
| Volume of Distribution | 1000.0 | L | 1000.0 | L | DRUGBANK | Volume of Distribution | 17.6 | L/kg | ~17.6 | L/kg | hydrolysis; hydrolysis; hydrolysis; | The Pharmacological Basis of Therapeutics |
| Half-life | 35.0 | h | 30-40 | h | terminal half-life; | DRUGBANK | Half-life | 46.7 | h | 40-53.3 | h | moderate hepatic impairment; | DRUGBANK | Half-life | 59.5 | h | 51-68 | h | severe hepatic impairment; | DRUGBANK | Half-life | 34.0 | h | 34±9 | h | chronic liver disease ↑ ; | The Pharmacological Basis of Therapeutics |
| Protein Binding | 95.0 | % | 93-97 | % | plasma proteins; | DRUGBANK | Protein Binding | 95.0 | % | 93-97 | % | The Pharmacological Basis of Therapeutics |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for adults | 300.0 | mg/day | 300 | mg/day | PO, oral | Sensipar | cinacalcet | PDR |
| Max dose for adults | 360.0 | mg/day | 360 | mg/day | PO, oral | Sensipar | cinacalcet | PDR |
| Max dose for geriatric | 300.0 | mg/day | 300 | mg/day | PO, oral | Sensipar | cinacalcet | PDR |
| Max dose for geriatric | 360.0 | mg/day | 360 | mg/day | PO, oral | Sensipar | cinacalcet | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1