Basic Information
| Drug ID | DDPD01011 |
|
| Drug Name | Metyrapone | |
| Molecular Weight | 226.2738 | |
| Molecular Formula | C14H14N2O | |
| CAS Number | 54-36-4 | |
| SMILES | CC(C)(C(=O)C1=CN=CC=C1)C1=CC=CN=C1 | |
| External Links | ||
| DRUGBANK | DB01011 | |
| PubChem Compound | 4174 | |
| PDR | 1990 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 1.8 | - | 1.8 | - | DRUGBANK |
| Melting Point | 50.5 | ℃ | 50.5 | ℃ | PhysProp |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| T Max | 1.0 | h | 1 | h | PO, oral; | DRUGBANK |
| Half-life | 1.9 | h | 1.9±0.7 | h | DRUGBANK | |
| Toxicity LD50 | 521.0 | mg/kg | 521.0 | mg/kg | PO, oral; Rattus, Rat; | DRUGBANK |
| Eliminate Route | 5.3 | % | 5.3 | % | Urinary excretion; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for children | 15.0 | mg/kg | 15 | mg/kg | PO, oral | Metopirone | metyrapone | PDR |
| Max dose for children | 3000.0 | mg | 3 | g | PO, oral | Metopirone | metyrapone | PDR |
| Max dose for children | 15.0 | mg/kg/dose/day | 15 | mg/kg/dose/day | PO, oral | Metopirone | metyrapone | PDR |
| Max dose for children | 4500.0 | mg/day | 4.5 | g/day | PO, oral | Metopirone | metyrapone | PDR |
| Max dose for adolescents | 3000.0 | mg/day | 3 | g/day | PO, oral | Metopirone | metyrapone | PDR |
| Max dose for adolescents | 4500.0 | mg/day | 4.5 | g/day | PO, oral | Metopirone | metyrapone | PDR |
| Max dose for adults | 3000.0 | mg/day | 3 | g/day | PO, oral | Metopirone | metyrapone | PDR |
| Max dose for adults | 4500.0 | mg/day | 4.5 | g/day | PO, oral | Metopirone | metyrapone | PDR |
| Max dose for elderly | 3000.0 | mg/day | 3 | g/day | PO, oral | Metopirone | metyrapone | PDR |
| Max dose for elderly | 4500.0 | mg/day | 4.5 | g/day | PO, oral | Metopirone | metyrapone | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1