Basic Information
| Drug ID | DDPD01009 |
|
| Drug Name | Ketoprofen | |
| Molecular Weight | 254.2806 | |
| Molecular Formula | C16H14O3 | |
| CAS Number | 22071-15-4 | |
| SMILES | CC(C(O)=O)C1=CC(=CC=C1)C(=O)C1=CC=CC=C1 | |
| External Links | ||
| DRUGBANK | DB01009 | |
| PubChem Compound | 3825 | |
| PDR | 1976 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 3.12 | - | 3.12 | - | SANGSTER (1993) |
| Melting Point | 94.0 | ℃ | 94 | ℃ | U.S. Patent 3,641,127. |
| Water Solubility | 51.0 | mg/L | 51 | mg/L | YALKOWSKY,SH & DANNENFELSER,RM 1992) |
| pKa | 4.45 | - | 4.45 | - | SANGSTER (1994) |
| Log S | -3.7 | - | -3.7 | - | ADME Research, USCD |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| T Max | 1.3 | h | 0.5-2 | h | PO, oral; | DRUGBANK |
| Clearance | 6.9 | L/h | 6.9±0.8 | L/h | Capsule, PO, Oral; | DRUGBANK |
| Clearance | 6.8 | L/h | 6.8±1.8 | L/h | Capsule, PO, Oral; | DRUGBANK |
| Clearance | 0.0800 | L/h/kg | 0.08 | L/kg/h | DRUGBANK | |
| Clearance | 0.70 | L/h/kg | 0.7 | L/kg/h | alcoholic liver disease; Hepatitis, Hep; | DRUGBANK |
| Clearance | 0.0960 | L/h/kg | 1.6 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 0.13 | L/kg | 0.13 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 2.6 | h | 1.1-4 | h | Capsule, PO, Oral; | DRUGBANK |
| Half-life | 5.4 | h | 5.4 | h | extended release formulation; Capsule, PO, Oral; | DRUGBANK |
| Half-life | 2.1 | h | 2.1 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Toxicity LD50 | 62.4 | mg/kg | 62.4 | mg/kg | PO, oral; Rattus, Rat; | DRUGBANK |
| Eliminate Route | 80.0 | % | ~80 | % | Urinary excretion; | DRUGBANK |
| Protein Binding | 99.0 | % | 99 | % | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for adolescents | 75.0 | mg/day | 75 | mg/day | PO, oral | Ketoprofen | ketoprofen | PDR |
| Max dose for adults | 300.0 | mg/day | 300 | mg/day | PO, oral | Ketoprofen | ketoprofen | PDR |
| Max dose for adults | 200.0 | mg/day | 200 | mg/day | PO, oral | Ketoprofen | ketoprofen | PDR |
| Max dose for adults | 75.0 | mg/day | 75 | mg/day | PO, oral | Ketoprofen | ketoprofen | PDR |
| Max dose for elderly | 300.0 | mg/day | 300 | mg/day | PO, oral | Ketoprofen | ketoprofen | PDR |
| Max dose for elderly | 200.0 | mg/day | 200 | mg/day | PO, oral | Ketoprofen | ketoprofen | PDR |
| Max dose for elderly | 75.0 | mg/day | 75 | mg/day | PO, oral | Ketoprofen | ketoprofen | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1