Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD01004 ...
Drug Name Ganciclovir
Molecular Weight 255.2306
Molecular Formula C9H13N5O4
CAS Number 82410-32-0
SMILES NC1=NC2=C(N=CN2COC(CO)CO)C(=O)N1
External Links
DRUGBANK DB01004
PubChem Compound 3454
PDR 1025
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Caco-2 Permeability -6.27 - -6.27 - ADME Research, USCD
Log P -1.66 - -1.66 - SANGSTER (1993)
Melting Point 250.0 ℃ 250 ℃ PhysProp
Water Solubility 4300.0 mg/L 4300 mg/L MERCK INDEX 1996); pH 7

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
Bioavailability 5.0 % 5 % PO, oral; fasting; DRUGBANK
Bioavailability 7.5 % 6-9 % DRUGBANK
Bioavailability 30.0 % 30 % DRUGBANK
Bioavailability 4.0 % 3-5 % PO, oral; The Pharmacological Basis of Therapeutics
C Max 1200.0 ng/ml 1.2±0.4 mcg/ml intravenous infusion, IV in drop; food; The Pharmacological Basis of Therapeutics
C Max 6600.0 ng/ml 6.6±1.8 mcg/ml The Pharmacological Basis of Therapeutics
T Max 3.0 h 3.0±0.6 h intravenous infusion, IV in drop; food; The Pharmacological Basis of Therapeutics
Metabolic 90.0 % ~90 % Urinary excretion; DRUGBANK
Clearance 7.7 L/h 128±63 ml/min mild renal function; patients; DRUGBANK
Clearance 3.4 L/h 57±8 ml/min moderate renal function; patients; DRUGBANK
Clearance 1.8 L/h 30±13 ml/min severe renal function; patients; DRUGBANK
Clearance 0.28 L/h 4.7±2.2 ml/min pediatric patients; DRUGBANK
Clearance 0.20 L/h/kg 3.4±0.5 ml/min/kg RD, renal impairment, Renal disease，including uremia ↓ ; The Pharmacological Basis of Therapeutics
Clearance 0.28 L/h/kg 4.6 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 0.74 L/kg 0.74±0.15 L/kg DRUGBANK
Volume of Distribution 1.1 L/kg 1.1±0.2 L/kg The Pharmacological Basis of Therapeutics
Volume of Distribution 1.0 L/kg 1 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 2.9 h 2.9(2.5-3.6) h intravenous injection, IV; adults; DRUGBANK
Half-life 4.3 h 3.1-5.5 h PO, oral; adults; DRUGBANK
Half-life 19.5 h 9-30 h intravenous injection, IV; RD, renal impairment, Renal disease，including uremia; DRUGBANK
Half-life 17.0 h 15.7-18.2 h PO, oral; RD, renal impairment, Renal disease，including uremia; DRUGBANK
Half-life 3.7 h 3.7±0.6 h RD, renal impairment, Renal disease，including uremia ↑ ; The Pharmacological Basis of Therapeutics
Half-life 3.7 h 3.7 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Toxicity LD50 2000.0 mg/kg >2 g/kg PO, oral; mouse; DRUGBANK
Toxicity LD50 150.0 mg/kg >150 mg/kg intravenous injection, IV; dog; DRUGBANK
Eliminate Route 91.0 % 91±5 % Urinary excretion; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 1.5 % 1-2 % DRUGBANK
Protein Binding 1.5 % 1-2 % The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for neonates 12.0 mg/kg/day 12 mg/kg/day intravenous injection, IV Cytovene ganciclovir sodium PDR
Max dose for infants 15.0 mg/kg/day 15 mg/kg/day intravenous injection, IV Cytovene ganciclovir sodium PDR
Max dose for children 15.0 mg/kg/day 15 mg/kg/day intravenous injection, IV Cytovene ganciclovir sodium PDR
Max dose for children 5.0 drop/day 5 drop/day ophthalmic administration Cytovene ganciclovir sodium PDR
Max dose for children 15.0 mg/kg/day 15 mg/kg/day intravenous injection, IV Cytovene ganciclovir sodium PDR
Max dose for adolescents 10.0 mg/kg/day 10 mg/kg/day intravenous injection, IV Cytovene ganciclovir sodium PDR
Max dose for adolescents 5.0 drop/day 5 drop/day ophthalmic administration Cytovene ganciclovir sodium PDR
Max dose for adults 10.0 mg/kg/day 10 mg/kg/day intravenous injection, IV Cytovene ganciclovir sodium PDR
Max dose for adults 5.0 drop/day 5 drop/day ophthalmic administration Cytovene ganciclovir sodium PDR
Max dose for geriatric 10.0 mg/kg/day 10 mg/kg/day intravenous injection, IV Cytovene ganciclovir sodium PDR
Max dose for geriatric 5.0 drop/day 5 drop/day ophthalmic administration Cytovene ganciclovir sodium PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1