Basic Information
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 3.6 | - | 3.6 | - | DRUGBANK |
| pKa | 8.1 | - | 8.1 | - | DRUGBANK |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| C Max | 1200.0 | ng/ml | 1.2 | ug/ml | epidural administration; | DRUGBANK |
| T Max | 0.50 | h | 0.5 | h | epidural administration; | DRUGBANK |
| Metabolic | 0 | % | 0 | % | Urinary excretion; Faeces excretion; | DRUGBANK |
| Clearance | 39.1 | L/h | 39.06±13.29 | L/h | intravenous injection, IV; normal,healthy; | DRUGBANK | Clearance | 0.52 | L/h/kg | 8.7 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 66.9 | L | 66.91±18.23 | L | intravenous injection, IV; normal,healthy; | DRUGBANK | Volume of Distribution | 0.49 | L/kg | 0.49 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 3.3 | h | 3.3 | h | DRUGBANK | Half-life | 0.79 | h | 0.79 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Toxicity LD50 | 5.1 | mg/kg | 5.1 | mg/kg | intravenous injection, IV; rabbit; | DRUGBANK | Toxicity LD50 | 18.0 | mg/kg | 18.0 | mg/kg | PO, oral; rabbit; | DRUGBANK | Toxicity LD50 | 207.0 | mg/kg | 207.0 | mg/kg | parenteral administration; rabbit; | DRUGBANK | Toxicity LD50 | 63.0 | mg/kg | 63.0 | mg/kg | subcutaneous injection, SC; Rattus, Rat; | DRUGBANK | Toxicity LD50 | 5.1 | mg/kg | 5.1 | mg/kg | intravenous injection, IV; rabbit; | T3DB | Toxicity LD50 | 18.0 | mg/kg | 18.0 | mg/kg | PO, oral; rabbit; | T3DB | Toxicity LD50 | 207.0 | mg/kg | 207.0 | mg/kg | parenteral administration; rabbit; | T3DB | Toxicity LD50 | 63.0 | mg/kg | 63.0 | mg/kg | intravenous injection, IV; Rattus, Rat; | T3DB |
| Eliminate Route | 71.0 | % | ~71 | % | Urinary excretion; human, homo sapiens; | DRUGBANK | Eliminate Route | 24.0 | % | ~24 | % | Faeces excretion; human, homo sapiens; | DRUGBANK |
| Protein Binding | 97.0 | % | >97 | % | DRUGBANK |
Maximum Dosage
Not Available
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1