Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD01001 ...
Drug Name Salbutamol
Molecular Weight 239.3107
Molecular Formula C13H21NO3
CAS Number 18559-94-9
SMILES CC(C)(C)NCC(O)C1=CC(CO)=C(O)C=C1
External Links
DRUGBANK DB01001
T3DB T3D4735
PubChem Compound 2083
PDR 1426

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 1.4 - 1.4 - DRUGBANK
Melting Point 148.0 ℃ 147-149 ℃ Lunts, L.H.C. and Toon, P.; U.S. Patent 3,644,353; February 22,1972; assigned to Allen & Hanburys Ltd.
Water Solubility 14100.0 mg/L 14100 mg/L YALKOWSKY,SH & HE,Y 2003)
pKa 10.3 - 10.3 - DRUGBANK
Log S -1.22 - -1.22 - ADME Research, USCD

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
Bioavailability 30.0 % 30±7 % PO, oral; Optical rotation R; The Pharmacological Basis of Therapeutics
Bioavailability 71.0 % 71±9 % PO, oral; Optical rotation S; The Pharmacological Basis of Therapeutics
Bioavailability 25.0 % 25.0 % inhalation, IH; Optical rotation R; The Pharmacological Basis of Therapeutics
Bioavailability 47.0 % 47.0 % inhalation, IH; Optical rotation S; The Pharmacological Basis of Therapeutics
C Max 3.0 ng/ml 3 ng/ml PO, oral; Active metabolite; DRUGBANK
C Max 3.6 ng/ml 3.6(1.9-5.9) ng/ml Oral single dose; Optical rotation R; The Pharmacological Basis of Therapeutics
C Max 11.4 ng/ml 11.4(7.1-16.2) ng/ml Oral single dose; Optical rotation S; The Pharmacological Basis of Therapeutics
T Max 0.17 h 0.17 h PO, oral; Active metabolite; DRUGBANK
T Max 0.42 h 0.42 h PO, oral; Active metabolite; DRUGBANK
T Max 1.5 h 1.5 h Oral single dose; Optical rotation R; The Pharmacological Basis of Therapeutics
T Max 2.0 h 2.0 h Oral single dose; Optical rotation S; The Pharmacological Basis of Therapeutics
Metabolic 0 % 0 % lung metabolism; DRUGBANK
Clearance 16.3 L/h 272±38 ml/min Renal clearance; PO, oral; DRUGBANK
Clearance 17.5 L/h 291±70 ml/min Renal clearance; intravenous injection, IV; DRUGBANK
Clearance 5.9 L/h 98.5±23.5 ml/min Renal clearance; PO, oral; DRUGBANK
Clearance 0.62 L/h/kg 10.3±3.0 ml/min/kg RD, renal impairment, Renal disease，including uremia ↓ ; The Pharmacological Basis of Therapeutics
Clearance 0.39 L/h/kg 6.5±2.0 ml/min/kg RD, renal impairment, Renal disease，including uremia ↓ ; The Pharmacological Basis of Therapeutics
Volume of Distribution 156.0 L 156±38 L intravenous injection, IV; DRUGBANK
Volume of Distribution 2.0 L/kg 2.00±0.70 L/kg RD, renal impairment, Renal disease，including uremia ↓ ; The Pharmacological Basis of Therapeutics
Volume of Distribution 1.8 L/kg 1.77±0.69 L/kg RD, renal impairment, Renal disease，including uremia ↓ ; The Pharmacological Basis of Therapeutics
Half-life 3.9 h 2.7-5 h elimination half-life; PO, oral; DRUGBANK
Half-life 3.9 h 2.7-5 h elimination half-life; inhalation, IH; DRUGBANK
Half-life 4.6 h ~4.6 h terminal half-life; DRUGBANK
Half-life 2.0 h 2.00±0.49 h normal,healthy; Optical rotation R; RD, renal impairment, Renal disease，including uremia ↓ ; The Pharmacological Basis of Therapeutics
Half-life 2.9 h 2.85±0.85 h normal,healthy; Optical rotation S; RD, renal impairment, Renal disease，including uremia ↓ ; The Pharmacological Basis of Therapeutics
Toxicity LD50 1100.0 mg/kg 1100.0 mg/kg PO, oral; mouse; DRUGBANK
Toxicity LD50 1100.0 mg/kg 1100.0 mg/kg PO, oral; mouse; T3DB
Eliminate Route 68.0 % 58-78 % Urinary excretion; PO, oral; DRUGBANK
Eliminate Route 46.0 % 46±8 % Urinary excretion; Optical rotation R; normal,healthy; human, homo sapiens; Unchanged drug; The Pharmacological Basis of Therapeutics
Eliminate Route 55.0 % 55±11 % Urinary excretion; Optical rotation S; normal,healthy; human, homo sapiens; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 7.0 % 7±1 % Optical rotation R/S; normal,healthy; human, homo sapiens; The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for children 24.0 mg/day 24 mg/day Tablet,PO，oral;Liquid; Albuterol Sulfate Inhalation Solution 0.5% albuterol sulfate PDR
Max dose for children 12.0 puffs/day 12 puffs/day inhalation, IH Albuterol Sulfate Inhalation Solution 0.5% albuterol sulfate PDR
Max dose for children 4.0 dose/day 4 dose/day inhalation, IH Albuterol Sulfate Inhalation Solution 0.5% albuterol sulfate PDR
Max dose for children 10.0 mg/day 10 mg/day inhalation, IH Albuterol Sulfate Inhalation Solution 0.5% albuterol sulfate PDR
Max dose for children 2.5 mg/day 2.5 mg/day inhalation, IH Albuterol Sulfate Inhalation Solution 0.5% albuterol sulfate PDR
Max dose for children 5.0 mg/day 5 mg/day inhalation, IH Albuterol Sulfate Inhalation Solution 0.5% albuterol sulfate PDR
Max dose for children 0.6 mg/kg/day 0.6 mg/kg/day Liquid Albuterol Sulfate Inhalation Solution 0.5% albuterol sulfate PDR
Max dose for children 12.0 mg/day 12 mg/day Liquid Albuterol Sulfate Inhalation Solution 0.5% albuterol sulfate PDR
Max dose for children 12.0 puffs/day 12 puffs/day inhalation, IH Albuterol Sulfate Inhalation Solution 0.5% albuterol sulfate PDR
Max dose for children 4.0 dose/day 4 dose/day inhalation, IH Albuterol Sulfate Inhalation Solution 0.5% albuterol sulfate PDR
Max dose for children 10.0 mg/day 10 mg/day inhalation, IH Albuterol Sulfate Inhalation Solution 0.5% albuterol sulfate PDR
Max dose for children 2.5 mg/day 2.5 mg/day inhalation, IH Albuterol Sulfate Inhalation Solution 0.5% albuterol sulfate PDR
Max dose for children 5.0 mg/day 5 mg/day inhalation, IH Albuterol Sulfate Inhalation Solution 0.5% albuterol sulfate PDR
Max dose for children 0.6 mg/kg/day 0.6 mg/kg/day Liquid Albuterol Sulfate Inhalation Solution 0.5% albuterol sulfate PDR
Max dose for children 12.0 mg/day 12 mg/day Liquid Albuterol Sulfate Inhalation Solution 0.5% albuterol sulfate PDR
Max dose for children 4.0 dose/day 4 dose/day inhalation, IH Albuterol Sulfate Inhalation Solution 0.5% albuterol sulfate PDR
Max dose for children 10.0 mg/day 10 mg/day inhalation, IH Albuterol Sulfate Inhalation Solution 0.5% albuterol sulfate PDR
Max dose for children 2.5 mg/day 2.5 mg/day inhalation, IH Albuterol Sulfate Inhalation Solution 0.5% albuterol sulfate PDR
Max dose for children 5.0 mg/day 5 mg/day inhalation, IH Albuterol Sulfate Inhalation Solution 0.5% albuterol sulfate PDR
Max dose for adolescents 32.0 mg/day 32 mg/day Tablet,PO，oral;Liquid; Albuterol Sulfate Inhalation Solution 0.5% albuterol sulfate PDR
Max dose for adolescents 12.0 puffs/day 12 puffs/day inhalation, IH Albuterol Sulfate Inhalation Solution 0.5% albuterol sulfate PDR
Max dose for adolescents 4.0 dose/day 4 dose/day inhalation, IH Albuterol Sulfate Inhalation Solution 0.5% albuterol sulfate PDR
Max dose for adolescents 10.0 mg/day 10 mg/day inhalation, IH Albuterol Sulfate Inhalation Solution 0.5% albuterol sulfate PDR
Max dose for adolescents 2.5 mg/day 2.5 mg/day inhalation, IH Albuterol Sulfate Inhalation Solution 0.5% albuterol sulfate PDR
Max dose for adolescents 5.0 mg/day 5 mg/day inhalation, IH Albuterol Sulfate Inhalation Solution 0.5% albuterol sulfate PDR
Max dose for adolescents 24.0 mg/day 24 mg/day Liquid Albuterol Sulfate Inhalation Solution 0.5% albuterol sulfate PDR
Max dose for adolescents 32.0 mg/day 32 mg/day Tablet,PO，oral Albuterol Sulfate Inhalation Solution 0.5% albuterol sulfate PDR
Max dose for adolescents 12.0 puffs/day 12 puffs/day inhalation, IH Albuterol Sulfate Inhalation Solution 0.5% albuterol sulfate PDR
Max dose for adolescents 4.0 dose/day 4 dose/day inhalation, IH Albuterol Sulfate Inhalation Solution 0.5% albuterol sulfate PDR
Max dose for adolescents 10.0 mg/day 10 mg/day inhalation, IH Albuterol Sulfate Inhalation Solution 0.5% albuterol sulfate PDR
Max dose for adolescents 2.5 mg/day 2.5 mg/day inhalation, IH Albuterol Sulfate Inhalation Solution 0.5% albuterol sulfate PDR
Max dose for adolescents 5.0 mg/day 5 mg/day inhalation, IH Albuterol Sulfate Inhalation Solution 0.5% albuterol sulfate PDR
Max dose for adults 32.0 mg/day 32 mg/day Tablet,PO，oral;Liquid; Albuterol Sulfate Inhalation Solution 0.5% albuterol sulfate PDR
Max dose for adults 12.0 puffs/day 12 puffs/day inhalation, IH Albuterol Sulfate Inhalation Solution 0.5% albuterol sulfate PDR
Max dose for adults 4.0 dose/day 4 dose/day inhalation, IH Albuterol Sulfate Inhalation Solution 0.5% albuterol sulfate PDR
Max dose for adults 10.0 mg/day 10 mg/day inhalation, IH Albuterol Sulfate Inhalation Solution 0.5% albuterol sulfate PDR
Max dose for adults 2.5 mg/day 2.5 mg/day inhalation, IH Albuterol Sulfate Inhalation Solution 0.5% albuterol sulfate PDR
Max dose for adults 5.0 mg/day 5 mg/day inhalation, IH Albuterol Sulfate Inhalation Solution 0.5% albuterol sulfate PDR
Max dose for geriatric 32.0 mg/day 32 mg/day Tablet,PO，oral;Liquid; Albuterol Sulfate Inhalation Solution 0.5% albuterol sulfate PDR
Max dose for geriatric 12.0 puffs/day 12 puffs/day inhalation, IH Albuterol Sulfate Inhalation Solution 0.5% albuterol sulfate PDR
Max dose for geriatric 4.0 dose/day 4 dose/day inhalation, IH Albuterol Sulfate Inhalation Solution 0.5% albuterol sulfate PDR
Max dose for geriatric 10.0 mg/day 10 mg/day inhalation, IH Albuterol Sulfate Inhalation Solution 0.5% albuterol sulfate PDR
Max dose for geriatric 2.5 mg/day 2.5 mg/day inhalation, IH Albuterol Sulfate Inhalation Solution 0.5% albuterol sulfate PDR
Max dose for geriatric 5.0 mg/day 5 mg/day inhalation, IH Albuterol Sulfate Inhalation Solution 0.5% albuterol sulfate PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1