Basic Information
| Drug ID | DDPD00998 |
|
| Drug Name | Frovatriptan | |
| Molecular Weight | 243.3043 | |
| Molecular Formula | C14H17N3O | |
| CAS Number | 158747-02-5 | |
| SMILES | CN[C@@H]1CCC2=C(C1)C1=C(N2)C=CC(=C1)C(N)=O | |
| External Links | ||
| DRUGBANK | DB00998 | |
| T3DB | T3D2954 | |
| PubChem Compound | 77992 | |
| PDR | 2246 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 0.9 | - | 0.9 | - | DRUGBANK |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Clearance | 13.2 | L/h | 220.0 | ml/min | intravenous injection, IV; Male, men; | DRUGBANK | Clearance | 7.8 | L/h | 130.0 | ml/min | intravenous injection, IV; Female, women; | DRUGBANK | Clearance | 0.15 | L/h/kg | 2.5 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 4.2 | L/kg | 4.2 | L/kg | Male, men; | DRUGBANK | Volume of Distribution | 3.0 | L/kg | 3.0 | L/kg | Female, women; | DRUGBANK | Volume of Distribution | 3.6 | L/kg | 3.6 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 26.0 | h | 26 | h | DRUGBANK | Half-life | 24.0 | h | 24 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Eliminate Route | 10.0 | % | <10 | % | Urinary excretion; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for adults | 7.5 | mg/day | 7.5 | mg/day | PO, oral | Frova | frovatriptan succinate | PDR |
| Max dose for geriatric | 7.5 | mg/day | 7.5 | mg/day | PO, oral | Frova | frovatriptan succinate | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1