Basic Information
| Drug ID | DDPD00993 |
|
| Drug Name | Azathioprine | |
| Molecular Weight | 277.263 | |
| Molecular Formula | C9H7N7O2S | |
| CAS Number | 446-86-6 | |
| SMILES | CN1C=NC(=C1SC1=NC=NC2=C1NC=N2)[N+]([O-])=O | |
| External Links | ||
| DRUGBANK | DB00993 | |
| T3DB | T3D4677 | |
| PubChem Compound | 2265 | |
| PDR | 1892 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 0.1 | - | 0.1 | - | HANSCH,C ET AL. (1995) |
| Melting Point | 243.5 | ℃ | 243.5 | ℃ | PhysProp |
| pKa | 7.87 | - | 7.87 | - | MITRA,AK & NARURKAR,MM (1986) |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Factor | Reference |
|---|---|---|---|---|---|---|---|
| Bioavailability | 60.0 | % | 60±31 | % | PO, oral; | The Pharmacological Basis of Therapeutics | |
| C Max | 55.0 | ng/ml | 20-90 | ng/ml | PO, oral; Active metabolite; renal transplant; | The Pharmacological Basis of Therapeutics | |
| T Max | 1.5 | h | 1-2 | h | PO, oral; | DRUGBANK | T Max | 1.5 | h | 1-2 | h | PO, oral; Active metabolite; renal transplant; | The Pharmacological Basis of Therapeutics |
| Clearance | 3.4 | L/h/kg | 57±31 | ml/min/kg | renal transplant; intravenous injection, IV; | The Pharmacological Basis of Therapeutics | |
| Volume of Distribution | 0.81 | L/kg | 0.81±0.65 | L/kg | renal transplant; intravenous injection, IV; | The Pharmacological Basis of Therapeutics | |
| Half-life | 5.0 | h | ~5 | h | DRUGBANK | Half-life | 0.16 | h | 0.16±0.07 | h | renal transplant; patients; | RD, renal impairment, Renal disease，including uremia → ; | The Pharmacological Basis of Therapeutics |
| Toxicity LD50 | 2500.0 | mg/kg | 2500.0 | mg/kg | PO, oral; mouse; | DRUGBANK | Toxicity LD50 | 400.0 | mg/kg | 400.0 | mg/kg | PO, oral; Rattus, Rat; | DRUGBANK | Toxicity LD50 | 2500.0 | mg/kg | 2500.0 | mg/kg | Oral single dose; mouse; | T3DB | Toxicity LD50 | 400.0 | mg/kg | 400.0 | mg/kg | Oral single dose; Rattus, Rat; | T3DB |
| Eliminate Route | 2.0 | % | <2 | % | Urinary excretion; intravenous injection, IV; Unchanged drug; | The Pharmacological Basis of Therapeutics | |
| Protein Binding | 30.0 | % | 30 | % | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for children | 1.5 | mg/kg/day | 1.5 | mg/kg/day | PO, oral | Azasan | azathioprine | PDR |
| Max dose for adolescents | 1.5 | mg/kg/day | 1.5 | mg/kg/day | PO, oral | Azasan | azathioprine | PDR |
| Max dose for adults | 2.5 | mg/kg/day | 2.5 | mg/kg/day | PO, oral | Azasan | azathioprine | PDR |
| Max dose for adults | 4.0 | mg/kg/day | 4 | mg/kg/day | PO, oral;intravenous injection, IV; | Azasan | azathioprine | PDR |
| Max dose for elderly | 2.5 | mg/kg/day | 2.5 | mg/kg/day | PO, oral | Azasan | azathioprine | PDR |
| Max dose for elderly | 4.0 | mg/kg/day | 4 | mg/kg/day | PO, oral;intravenous injection, IV; | Azasan | azathioprine | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1