Basic Information
| Drug ID | DDPD00991 |
|
| Drug Name | Oxaprozin | |
| Molecular Weight | 293.3166 | |
| Molecular Formula | C18H15NO3 | |
| CAS Number | 21256-18-8 | |
| SMILES | OC(=O)CCC1=NC(=C(O1)C1=CC=CC=C1)C1=CC=CC=C1 | |
| External Links | ||
| DRUGBANK | DB00991 | |
| PubChem Compound | 4614 | |
| PDR | 1851 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 4.19 | - | 4.19 | - | HANSCH,C ET AL. (1995) |
| Melting Point | 158.5 | ℃ | 158-159 | ℃ | DRUGBANK |
| pKa | 4.3 | - | 4.3 | - | DRUGBANK |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Factor | Reference |
|---|---|---|---|---|---|---|---|
| Absorption | 95.0 | % | 95 | % | PO, oral; antacids; | antacids → ; | DRUGBANK |
| Volume of Distribution | 0.20 | L/kg | 11.0-17 | L/70kg | DRUGBANK | ||
| Half-life | 54.9 | h | 54.9 | h | DRUGBANK | ||
| Toxicity LD50 | 1210.0 | mg/kg | 1210.0 | mg/kg | PO, oral; mouse; | DRUGBANK | Toxicity LD50 | 172.0 | mg/kg | 172.0 | mg/kg | PO, oral; rabbit; | DRUGBANK | Toxicity LD50 | 4470.0 | mg/kg | 4470.0 | mg/kg | PO, oral; Rattus, Rat; | DRUGBANK |
| Eliminate Route | 70.0 | % | ~70 | % | Urinary excretion; | DRUGBANK | Eliminate Route | 5.0 | % | ~5 | % | Urinary excretion; Unchanged drug; | DRUGBANK |
| Protein Binding | 99.5 | % | >99.5 | % | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for children | 1200.0 | mg/day | 1200 | mg/day | PO, oral | Daypro | oxaprozin | PDR |
| Max dose for adolescents | 1200.0 | mg/day | 1200 | mg/day | PO, oral | Daypro | oxaprozin | PDR |
| Max dose for adults | 1800.0 | mg/day | 1800 | mg/day | PO, oral | Daypro | oxaprozin | PDR |
| Max dose for adults | 26.0 | mg/kg/day | 26 | mg/kg/day | PO, oral | Daypro | oxaprozin | PDR |
| Max dose for adults | 1200.0 | mg/day | 1200 | mg/day | PO, oral | Daypro | oxaprozin | PDR |
| Max dose for elderly | 1800.0 | mg/day | 1800 | mg/day | PO, oral | Daypro | oxaprozin | PDR |
| Max dose for elderly | 26.0 | mg/kg/day | 26 | mg/kg/day | PO, oral | Daypro | oxaprozin | PDR |
| Max dose for elderly | 1200.0 | mg/day | 1200 | mg/day | PO, oral | Daypro | oxaprozin | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1