Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00983 ...
Drug Name Formoterol
Molecular Weight 344.4049
Molecular Formula C19H24N2O4
CAS Number 73573-87-2
SMILES COC1=CC=C(CC(C)NCC(O)C2=CC(NC=O)=C(O)C=C2)C=C1
External Links
DRUGBANK DB00983
PubChem Compound 3410
PDR 135
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 2.2 - 2.2 - DRUGBANK

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
Absorption 60.0 % 60 % inhalation, IH; adults; normal,healthy; DRUGBANK
AUC 0.0279 ng.h/ml 81.0 pmol.h/L inhalation, IH; adults; normal,healthy; DRUGBANK
AUC 0.0431 ng.h/ml 125.0 pmol.h/L adults; asthma; DRUGBANK
AUC 0.0778 ng.h/ml 226.0 pmol.h/L adults; asthma; DRUGBANK
C Max 0.000022 ng/ml 22 pmol/L inhalation, IH; adults; normal,healthy; DRUGBANK
C Max 0.000022 ng/ml 22 pmol/L adults; asthma; DRUGBANK
C Max 0.000041 ng/ml 41 pmol/L adults; asthma; DRUGBANK
T Max 0.33 h 0.167-0.5 h inhalation, IH; adults; normal,healthy; DRUGBANK
T Max 1.3 h 0.58-1.97 h adults; asthma; DRUGBANK
Clearance 9.4 L/h 157.0 ml/min Renal clearance; DRUGBANK
Half-life 8.5 h 7-10 h elimination half-life; inhalation, IH; DRUGBANK
Half-life 3.5 h 3-4 h elimination half-life; PO, oral; DRUGBANK
Half-life 2.0 h 1.7-2.3 h elimination half-life; inhalation, IH; DRUGBANK
Toxicity LD50 3130.0 mg/kg 3130.0 mg/kg PO, oral; Rattus, Rat; DRUGBANK
Eliminate Route 60.5 % ~59-62 % Urinary excretion; PO, oral; normal,healthy; human, homo sapiens; DRUGBANK
Eliminate Route 33.0 % ~32-34 % Faeces excretion; PO, oral; normal,healthy; human, homo sapiens; DRUGBANK
Eliminate Route 10.0 % ~10 % Urinary excretion; asthma; Unchanged drug; DRUGBANK
Protein Binding 34.5 % 31-38 % DRUGBANK

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for adults 0.04 mg/day 40 mcg/day skin/dermal Perforomist formoterol fumarate PDR
Max dose for geriatric 0.04 mg/day 40 mcg/day skin/dermal Perforomist formoterol fumarate PDR

Drug Property Radar Chart

...

Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1