DETAILS

Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID	DDPD00978
Drug Name	Lomefloxacin
Molecular Weight	351.3479
Molecular Formula	C17H19F2N3O3
CAS Number	98079-51-7
SMILES	CCN1C=C(C(O)=O)C(=O)C2=CC(F)=C(N3CCNC(C)C3)C(F)=C12
External Links
	DRUGBANK	DB00978
	PubChem Compound	3948
	Drugs.com	Drugs.com Drug Page

Experimental Physicochemical Property

Property Name	Property Value	Unit	Raw Value	Raw Unit	Reference
Log P	-0.3	-	-0.3	-	TAKACS-NOVAK,K ET AL. (1992)
Melting Point	239.75	℃	239-240.5	℃	PhysProp
Water Solubility	27200.0	mg/L	27.2	mg/ml	DRUGBANK

Pharmacokinetic/ Toxicokinetic Property

Property Name	Property Value	Unit	Raw Value	Raw Unit	Annotation	Reference
Absorption	96.5	%	95-98	%	Oral single dose;	DRUGBANK
Metabolic	65.0	%	65	%	Urinary excretion; Unchanged drug;	DRUGBANK
Metabolic	9.0	%	9	%	Urinary excretion;	DRUGBANK
Clearance	9.4	L/h/m2	271.0	ml/min/1.73m2	normal,healthy;	DRUGBANK
Clearance	1.1	L/h/m2	31.0	ml/min/1.73m2	renal insufficiency;	DRUGBANK
Clearance	0.24	L/h/kg	3.98	ml/min/kg	intravenous injection, IV; human, homo sapiens;	Human Intravenous Pharmacokinetic Dataset
Volume of Distribution	2.0	L/kg	2.04	L/kg	intravenous injection, IV; human, homo sapiens;	Human Intravenous Pharmacokinetic Dataset
Half-life	8.0	h	8	h		DRUGBANK
Half-life	8.1	h	8.1	h	intravenous injection, IV; human, homo sapiens;	Human Intravenous Pharmacokinetic Dataset
Protein Binding	10.0	%	10	%		DRUGBANK

Maximum Dosage

Not Available

Drug Property Radar Chart

Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1