Basic Information
| Drug ID | DDPD00978 |
|
| Drug Name | Lomefloxacin | |
| Molecular Weight | 351.3479 | |
| Molecular Formula | C17H19F2N3O3 | |
| CAS Number | 98079-51-7 | |
| SMILES | CCN1C=C(C(O)=O)C(=O)C2=CC(F)=C(N3CCNC(C)C3)C(F)=C12 | |
| External Links | ||
| DRUGBANK | DB00978 | |
| PubChem Compound | 3948 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | -0.3 | - | -0.3 | - | TAKACS-NOVAK,K ET AL. (1992) |
| Melting Point | 239.75 | ℃ | 239-240.5 | ℃ | PhysProp |
| Water Solubility | 27200.0 | mg/L | 27.2 | mg/ml | DRUGBANK |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Absorption | 96.5 | % | 95-98 | % | Oral single dose; | DRUGBANK |
| Metabolic | 65.0 | % | 65 | % | Urinary excretion; Unchanged drug; | DRUGBANK |
| Metabolic | 9.0 | % | 9 | % | Urinary excretion; | DRUGBANK |
| Clearance | 9.4 | L/h/m2 | 271.0 | ml/min/1.73m2 | normal,healthy; | DRUGBANK |
| Clearance | 1.1 | L/h/m2 | 31.0 | ml/min/1.73m2 | renal insufficiency; | DRUGBANK |
| Clearance | 0.24 | L/h/kg | 3.98 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 2.0 | L/kg | 2.04 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 8.0 | h | 8 | h | DRUGBANK | |
| Half-life | 8.1 | h | 8.1 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Protein Binding | 10.0 | % | 10 | % | DRUGBANK |
Maximum Dosage
Not Available
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1