Basic Information
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 3.67 | - | 3.67 | - | HANSCH,C ET AL. (1995) |
| Melting Point | 143.0 | ℃ | 142-144 | ℃ | Inhoffen, H.H. and Hohlweg, W.; U.S. Patent 2,265,976; December 9, 1941; assigned to Schering Corp. |
| Water Solubility | 11.3 | mg/L | 11.3 | mg/L | YALKOWSKY,SH & DANNENFELSER,RM 1992) |
| Log S | -4.3 | - | -4.3 | - | ADME Research, USCD |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| AUC | 0.49 | ng.h/ml | 487.4±166.6 | pg.h/ml | PO, oral; | DRUGBANK | AUC | 3.9 | ng.h/ml | 3895±1423 | pg.h/ml | Transdermal preparations; | DRUGBANK |
| C Max | 0.0741 | ng/ml | 74.1±35.6 | pg/ml | PO, oral; | DRUGBANK | C Max | 0.0288 | ng/ml | 28.8±10.3 | pg/ml | Transdermal preparations; | DRUGBANK |
| T Max | 1.5 | h | 1.5±0.5 | h | PO, oral; | DRUGBANK | T Max | 86.0 | h | 86±31 | h | Transdermal preparations; | DRUGBANK |
| Clearance | 16.5 | L/h | 16.47 | L/h | intravenous injection, IV; | DRUGBANK | Clearance | 2.1 | L/h | ~2.1 | L/h | Renal clearance; | DRUGBANK | Clearance | 58.0 | L/h | 58.0±19.8 | L/h | PO, oral; | DRUGBANK | Clearance | 303.5 | L/h | 303.5±100.5 | L/h | skin/dermal; | DRUGBANK | Clearance | 0.42 | L/h/kg | 7 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 625.3 | L | 625.3±228.7 | L | Apparent volume of distribution; PO, oral; | DRUGBANK | Volume of Distribution | 11745.3 | L | 11745.3±15934.8 | L | Apparent volume of distribution; skin/dermal; | DRUGBANK | Volume of Distribution | 4.3 | L/kg | 4.3 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 8.4 | h | 8.4±4.8 | h | PO, oral; | DRUGBANK | Half-life | 27.7 | h | 27.7±34.2 | h | skin/dermal; | DRUGBANK | Half-life | 9.7 | h | 9.7 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Toxicity LD50 | 1737.0 | mg/kg | 1737.0 | mg/kg | PO, oral; mouse; | T3DB |
| Eliminate Route | 59.2 | % | 59.2 | % | Urinary excretion; Bile excretion; | DRUGBANK | Eliminate Route | 2.5 | % | 2-3 | % | Faeces excretion; | DRUGBANK |
| Protein Binding | 98.4 | % | 98.3-98.5 | % | DRUGBANK |
Maximum Dosage
Not Available
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1