Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00976 ...
Drug Name Telithromycin
Molecular Weight 812.018
Molecular Formula C43H65N5O10
CAS Number 191114-48-4
SMILES [H][C@@]12[C@@H](C)C(=O)[C@H](C)C[C@@](C)(OC)[C@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@@H](C)C(=O)[C@@H](C)C(=O)O[C@H](CC)[C@@]1(C)OC(=O)N2CCCCN1C=NC(=C1)C1=CC=CN=C1
External Links
DRUGBANK DB00976
T3DB T3D3536
PubChem Compound 3002190
PDR 519
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 3.0 - 3.0 - DRUGBANK
Melting Point 182.0 ℃ 176-188 ℃ DRUGBANK
Water Solubility 300.0 mg/L 300 mg/L DRUGBANK

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
Bioavailability 57.0 % ~57 % PO, oral; DRUGBANK
Bioavailability 57.0 % 57(41-112) % PO, oral; The Pharmacological Basis of Therapeutics
C Max 2230.0 ng/ml 2.23 mcg/ml PO, oral; The Pharmacological Basis of Therapeutics
T Max 2.3 h 0.5-4 h PO, oral; DRUGBANK
T Max 1.0 h 1.0（0.5-3.0） h PO, oral; The Pharmacological Basis of Therapeutics
Metabolic 50.0 % 50 % Liver metabolism; DRUGBANK
Clearance 0.84 L/h/kg 14（12-16） ml/min/kg hydrolysis; RD, renal impairment, Renal disease，including uremia ↓ ; The Pharmacological Basis of Therapeutics
Clearance 0.84 L/h/kg 14 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 2.9 L/kg 2.9 L/kg DRUGBANK
Volume of Distribution 3.0 L/kg 3.0（2.1-4.5） L/kg hydrolysis; The Pharmacological Basis of Therapeutics
Volume of Distribution 3.0 L/kg 3 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 12.5 h 12-13 h elimination half-life; DRUGBANK
Half-life 12.0 h 12(7-23) h The Pharmacological Basis of Therapeutics
Half-life 12.0 h 12 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Toxicity LD50 2000.0 mg/kg >2000 mg/kg PO, oral; Rattus, Rat; DRUGBANK
Toxicity LD50 2000.0 mg/kg >2000 mg/kg PO, oral; Rattus, Rat; T3DB
Eliminate Route 37.0 % 37 % lung excretion; DRUGBANK
Eliminate Route 7.0 % 7 % Faeces excretion; Unchanged drug; DRUGBANK
Eliminate Route 13.0 % 13 % Urinary excretion; Unchanged drug; DRUGBANK
Eliminate Route 23.0 % 23(19-27) % Urinary excretion; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 65.0 % 60-70 % DRUGBANK
Protein Binding 70.0 % 70 % The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for children 0.0 0 Ketek telithromycin PDR
Max dose for adolescents 0.0 0 Ketek telithromycin PDR
Max dose for adults 800.0 mg/day 800 mg/day PO, oral Ketek telithromycin PDR
Max dose for elderly 800.0 mg/day 800 mg/day PO, oral Ketek telithromycin PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1