Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00973 ...
Drug Name Ezetimibe
Molecular Weight 409.4252
Molecular Formula C24H21F2NO3
CAS Number 163222-33-1
SMILES [H][C@]1(CC[C@H](O)C2=CC=C(F)C=C2)C(=O)N(C2=CC=C(F)C=C2)[C@]1([H])C1=CC=C(O)C=C1
External Links
DRUGBANK DB00973
PubChem Compound 150311
PDR 401
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Melting Point 163.0 ℃ 163 ℃ FDA label

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
C Max 4.5 ng/ml 3.4-5.5 ng/ml Oral single dose; adults; fasting; DRUGBANK
C Max 58.0 ng/ml 45-71 ng/ml PO, oral; Active metabolite; DRUGBANK
C Max 122.0 ng/ml 122.0 ng/ml PO, oral; The Pharmacological Basis of Therapeutics
T Max 8.0 h 4-12 h Oral single dose; adults; fasting; DRUGBANK
T Max 1.5 h 1-2 h PO, oral; Active metabolite; DRUGBANK
T Max 1.0 h 1.0 h PO, oral; The Pharmacological Basis of Therapeutics
Clearance 0.40 L/h/kg 6.6 ml/min/kg apparent clearance; Elderly ↓ ;hepatopathy，LD ↓ ;RD, renal impairment, Renal disease，including uremia ↓ ; The Pharmacological Basis of Therapeutics
Volume of Distribution 107.5 L 107.5 L Total volume of distribution; DRUGBANK
Volume of Distribution 1.6 L/kg 1.5 L/kg Apparent volume of distribution; The Pharmacological Basis of Therapeutics
Half-life 22.0 h 22 h DRUGBANK
Half-life 22.0 h 22 h DRUGBANK
Half-life 29.0 h 28-30 h effective half-life; The Pharmacological Basis of Therapeutics
Toxicity LD50 2000.0 mg/kg >2000 mg/kg PO, oral; Intraperitoneal, IP; Rattus, Rat; DRUGBANK
Toxicity LD50 5000.0 mg/kg >5000 mg/kg PO, oral; mouse; DRUGBANK
Toxicity LD50 3000.0 mg/kg >3000 mg/kg PO, oral; dog; DRUGBANK
Eliminate Route 78.0 % ~78 % Faeces excretion; PO, oral; DRUGBANK
Eliminate Route 11.0 % ~11 % Urinary excretion; PO, oral; DRUGBANK
Eliminate Route 69.0 % ~69 % Faeces excretion; PO, oral; Unchanged drug; DRUGBANK
Eliminate Route 2.0 % ~2 % Urinary excretion; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 90.0 % >90 % plasma proteins; human, homo sapiens; DRUGBANK
Protein Binding 99.7 % 99.5-99.8 % plasma proteins; high protein binding; human, homo sapiens; DRUGBANK
Protein Binding 90.0 % >90 % The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for children 10.0 mg/day 10 mg/day PO, oral Zetia ezetimibe PDR
Max dose for adolescents 10.0 mg/day 10 mg/day PO, oral Zetia ezetimibe PDR
Max dose for adults 10.0 mg/day 10 mg/day PO, oral Zetia ezetimibe PDR
Max dose for geriatric 10.0 mg/day 10 mg/day PO, oral Zetia ezetimibe PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1