Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00970 ...
Drug Name Dactinomycin
Molecular Weight 1255.417
Molecular Formula C62H86N12O16
CAS Number 50-76-0
SMILES [H][C@@]12CCCN1C(=O)[C@H](NC(=O)[C@@H](NC(=O)C1=C3N=C4C(OC3=C(C)C=C1)=C(C)C(=O)C(N)=C4C(=O)N[C@H]1[C@@H](C)OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@]3([H])CCCN3C(=O)[C@H](NC1=O)C(C)C)[C@@H](C)OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C2=O)C(C)C
External Links
DRUGBANK DB00970
PubChem Compound 457193
PDR 2057
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 1.6 - 1.6 - DRUGBANK
Melting Point 242.25 ℃ 241.5-243 ℃ DRUGBANK

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
Half-life 36.0 h 36 h DRUGBANK
Protein Binding 5.0 % 5 % DRUGBANK

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for infants 0.015 mg/kg/day 15 mcg/kg/day intravenous injection, IV Cosmegen dactinomycin PDR
Max dose for infants 0.045 mg/kg/dose 45 mcg/kg/dose intravenous injection, IV Cosmegen dactinomycin PDR
Max dose for infants 1250.0 mcg/m2/dose 1250 mcg/m2/dose intravenous injection, IV Cosmegen dactinomycin PDR
Max dose for infants 0.5 mg/m2/day 500 mcg/m2/day intravenous injection, IV Cosmegen dactinomycin PDR
Max dose for children 0.015 mg/kg/day 15 mcg/kg/day intravenous injection, IV Cosmegen dactinomycin PDR
Max dose for children 0.045 mg/kg/dose 45 mcg/kg/dose intravenous injection, IV Cosmegen dactinomycin PDR
Max dose for children 1250.0 mcg/m2/dose 1250 mcg/m2/dose intravenous injection, IV Cosmegen dactinomycin PDR
Max dose for children 0.5 mg/m2/day 500 mcg/m2/day intravenous injection, IV Cosmegen dactinomycin PDR
Max dose for adolescents 0.015 mg/kg/day 15 mcg/kg/day intravenous injection, IV Cosmegen dactinomycin PDR
Max dose for adolescents 0.045 mg/kg/dose 45 mcg/kg/dose intravenous injection, IV Cosmegen dactinomycin PDR
Max dose for adolescents 1.25 mg/m2/dose 1250 mcg/m2/dose intravenous injection, IV Cosmegen dactinomycin PDR
Max dose for adolescents 0.5 mg/m2/day 500 mcg/m2/day intravenous injection, IV Cosmegen dactinomycin PDR
Max dose for geriatric 0.015 mg/kg/day 15 mcg/kg/day intravenous injection, IV Cosmegen dactinomycin PDR
Max dose for geriatric 45.0 mcg/kg/dose 45 mcg/kg/dose intravenous injection, IV Cosmegen dactinomycin PDR
Max dose for geriatric 1250.0 mcg/m2/dose 1250 mcg/m2/dose intravenous injection, IV Cosmegen dactinomycin PDR
Max dose for geriatric 500.0 mcg/m2/day 500 mcg/m2/day intravenous injection, IV Cosmegen dactinomycin PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1