Basic Information
| Drug ID | DDPD00968 |
|
| Drug Name | Methyldopa | |
| Molecular Weight | 211.2145 | |
| Molecular Formula | C10H13NO4 | |
| CAS Number | 555-30-6 | |
| SMILES | C[C@](N)(CC1=CC=C(O)C(O)=C1)C(O)=O | |
| External Links | ||
| DRUGBANK | DB00968 | |
| T3DB | T3D3577 | |
| PubChem Compound | 38853 | |
| PDR | 1980 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | -1.7 | - | -1.7 | - | DRUGBANK |
| Melting Point | 300.0 | ℃ | 300 | ℃ | PhysProp |
| Water Solubility | 10000.0 | mg/L | 10000 | mg/L | MERCK INDEX 1996) |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Bioavailability | 50.0 | % | 50 | % | DRUGBANK | |
| Clearance | 7.8 | L/h | 130.0 | ml/min | Renal clearance; normal,healthy; | DRUGBANK | Clearance | 0.21 | L/h/kg | 3.5 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 0.69 | L/kg | 0.69 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 105.0 | h | 105 | h | elimination half-life; | DRUGBANK | Half-life | 5.9 | h | 5.9 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Toxicity LD50 | 1500.0 | mg/kg | >1.5 | g/kg | PO, oral; mouse; Rattus, Rat; | DRUGBANK | Toxicity LD50 | 1500.0 | mg/kg | >1.5 | g/kg | PO, oral; mouse; | T3DB | Toxicity LD50 | 1500.0 | mg/kg | >1.5 | g/kg | PO, oral; Rattus, Rat; | T3DB |
| Protein Binding | 20.0 | % | <20 | % | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for children | 65.0 | mg/kg/day | 65 | mg/kg/day | PO, oral;intravenous injection, IV; | Methyldopa | methyldopa | PDR |
| Max dose for children | 3000.0 | mg/day | 3 | g/day | PO, oral;intravenous injection, IV; | Methyldopa | methyldopa | PDR |
| Max dose for adolescents | 65.0 | mg/kg/day | 65 | mg/kg/day | PO, oral;intravenous injection, IV; | Methyldopa | methyldopa | PDR |
| Max dose for adolescents | 3000.0 | mg/day | 3 | g/day | PO, oral;intravenous injection, IV; | Methyldopa | methyldopa | PDR |
| Max dose for adults | 3000.0 | mg/day | 3 | g/day | PO, oral | Methyldopa | methyldopa | PDR |
| Max dose for adults | 4000.0 | mg/day | 4 | g/day | intravenous injection, IV | Methyldopa | methyldopa | PDR |
| Max dose for elderly | 1000.0 | mg/day | 1 | g/day | PO, oral;intravenous injection, IV; | Methyldopa | methyldopa | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1