Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00962 ...
Drug Name Zaleplon
Molecular Weight 305.3339
Molecular Formula C17H15N5O
CAS Number 151319-34-5
SMILES CCN(C(C)=O)C1=CC=CC(=C1)C1=CC=NC2=C(C=NN12)C#N
External Links
DRUGBANK DB00962
T3DB T3D2673
PubChem Compound 5719
PDR 1491
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 0.9 - 0.9 - DRUGBANK
Melting Point 158.0 ℃ 157-159 ℃ DRUGBANK

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
Absorption 100.0 % ~100 % PO, oral; DRUGBANK
Bioavailability 31.0 % 31±10 % Oral single dose; normal,healthy; The Pharmacological Basis of Therapeutics
C Max 26.0 ng/ml 26±4.4 ng/ml Oral single dose; normal,healthy; The Pharmacological Basis of Therapeutics
T Max 1.1 h 1.1±0.2 h Oral single dose; normal,healthy; The Pharmacological Basis of Therapeutics
Clearance 1.0 L/h/kg 1.0 l/h/kg DRUGBANK
Clearance 0.94 L/h/kg 15.7±3.3 ml/min/kg normal,healthy; Male, men;  Female, women; Elderly → ;Hepatic cirrhosis, cirr ↓ ; The Pharmacological Basis of Therapeutics
Clearance 0.96 L/h/kg 16 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 1.4 L/kg 1.4 L/kg DRUGBANK
Volume of Distribution 1.3 L/kg 1.3±0.2 L/kg normal,healthy; Male, men;  Female, women; The Pharmacological Basis of Therapeutics
Volume of Distribution 1.3 L/kg 1.3 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 1.0 h ~1 h DRUGBANK
Half-life 1.0 h 1.0±0.1 h normal,healthy; adults; Male, men;  Female, women; Hepatic cirrhosis, cirr ↑ ; The Pharmacological Basis of Therapeutics
Half-life 1.1 h 1.1 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Eliminate Route 1.0 % <1 % Urinary excretion; PO, oral; Unchanged drug; DRUGBANK
Eliminate Route 1.0 % <1 % Urinary excretion; adults; normal,healthy; human, homo sapiens; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 60.0 % ~60 % plasma proteins; high protein binding; DRUGBANK
Protein Binding 60.0 % 60±15 % adults; normal,healthy; human, homo sapiens; The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for adults 20.0 mg/day 20 mg/day PO, oral; hs Sonata zaleplon PDR
Max dose for adults 10.0 mg/day 10 mg/day PO, oral Sonata zaleplon PDR
Max dose for geriatric 10.0 mg/day 10 mg/day PO, oral; hs Sonata zaleplon PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1