Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00961 ...
Drug Name Mepivacaine
Molecular Weight 246.348
Molecular Formula C15H22N2O
CAS Number 96-88-8
SMILES CN1CCCCC1C(=O)NC1=C(C)C=CC=C1C
External Links
DRUGBANK DB00961
T3DB T3D2942
PubChem Compound 4062
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 1.95 - 1.95 - HANSCH,C ET AL. (1995)
Melting Point 150.5 ℃ 150.5 ℃ PhysProp
Water Solubility 7000.0 mg/L 7000 mg/L YALKOWSKY,SH & DANNENFELSER,RM 1992)
pKa 7.7 - 7.7 - SANGSTER (1994)
Log S -1.55 - -1.55 - ADME Research, USCD

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
Metabolic 50.0 % >50 % Bile excretion; DRUGBANK
Metabolic 7.5 % 5-10 % Urinary excretion; DRUGBANK
Clearance 0.41 L/h/kg 6.8 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 0.95 L/kg 0.95 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 2.6 h 1.9-3.2 h adults; DRUGBANK
Half-life 8.9 h 8.7-9 h Neonates; DRUGBANK
Half-life 2.0 h 2 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Toxicity LD50 29.0 mg/kg 23-35 mg/kg intravenous injection, IV; mouse; DRUGBANK
Toxicity LD50 280.0 mg/kg 280.0 mg/kg subcutaneous injection, SC; mouse; DRUGBANK
Toxicity LD50 29.0 mg/kg 23-35 mg/kg intravenous injection, IV; mouse; T3DB
Toxicity LD50 280.0 mg/kg 280.0 mg/kg subcutaneous injection, SC; mouse; T3DB
Eliminate Route 50.0 % >50 % Bile excretion; DRUGBANK
Eliminate Route 7.5 % 5-10 % Urinary excretion; Unchanged drug; DRUGBANK
Protein Binding 75.0 % ~75 % plasma proteins; DRUGBANK

Maximum Dosage

Not Available

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1