Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00958 ...
Drug Name Carboplatin
Molecular Weight 371.254
Molecular Formula C6H12N2O4Pt
CAS Number 41575-94-4
SMILES [H][N]([H])([H])[Pt]1(OC(=O)C2(CCC2)C(=O)O1)[N]([H])([H])[H]
External Links
DRUGBANK DB00958
PubChem Compound 38904
PDR 1537
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Not Available

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
C Max 39000.0 ng/ml 39±17 mcg/ml adults; ovarian cancer; The Pharmacological Basis of Therapeutics
T Max 0.50 h 0.5 h adults; ovarian cancer; The Pharmacological Basis of Therapeutics
Clearance 4.4 L/h 4.4 L/h Total clearance; intravenous injection, IV; DRUGBANK
Clearance 0.0900 L/h/kg 1.5±0.3 ml/min/kg RD, renal impairment, Renal disease，including uremia ↓ ; The Pharmacological Basis of Therapeutics
Clearance 0.0900 L/h/kg 1.5 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 16.0 L 16.0 L Apparent volume of distribution; intravenous injection, IV; DRUGBANK
Volume of Distribution 0.24 L/kg 0.24±0.03 L/kg The Pharmacological Basis of Therapeutics
Volume of Distribution 0.26 L/kg 0.26 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 1.6 h 1.1-2 h distribution half-life; DRUGBANK
Half-life 4.3 h 2.6-5.9 h elimination half-life; DRUGBANK
Half-life 2.0 h 2±0.2 h RD, renal impairment, Renal disease，including uremia ↑ ; The Pharmacological Basis of Therapeutics
Half-life 2.0 h 2 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Toxicity LD50 343.0 mg/kg 343.0 mg/kg PO, oral; Rattus, Rat; DRUGBANK
Toxicity LD50 72.0 mg/kg 72.0 mg/kg subcutaneous injection, SC; Rattus, Rat; DRUGBANK
Toxicity LD50 118.0 mg/kg 118.0 mg/kg Intraperitoneal, IP; mouse; DRUGBANK
Eliminate Route 77.0 % 77±5 % Urinary excretion; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 0 % 0 % The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for neonates 180000.0 ml/day 125 ml/min Carboplatin carboplatin PDR
Max dose for infants 125.0 ml/min 125 ml/min Carboplatin carboplatin PDR
Max dose for children 125.0 ml/min 125 ml/min Carboplatin carboplatin PDR
Max dose for adolescents 180000.0 ml/day 125 ml/min Carboplatin carboplatin PDR
Max dose for geriatric 125.0 ml/min 125 ml/min Carboplatin carboplatin PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1