Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00956 ...
Drug Name Hydrocodone
Molecular Weight 299.3642
Molecular Formula C18H21NO3
CAS Number 125-29-1
SMILES [H][C@@]12OC3=C(OC)C=CC4=C3[C@@]11CCN(C)[C@]([H])(C4)[C@]1([H])CCC2=O
External Links
DRUGBANK DB00956
T3DB T3D2941
PubChem Compound 5284569

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Melting Point 198.0 ℃ 198 ℃ PhysProp

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
C Max 6250000.0 ng 2.5-10 mg Liquid; DRUGBANK
C Max 70000000.0 ng 20-120 mg Tablet, PO, oral; extended release formulation; DRUGBANK
C Max 7937500.0 ng 3.175-12.7 mg Liquid; food; food ↑ ; DRUGBANK
C Max 88900000.0 ng 25.4-152.4 mg Tablet, PO, oral; extended release formulation; food; food ↑ ; DRUGBANK
C Max 30.0 ng/ml 30±9.4 ng/ml PO, oral; extensive metabolizers, EM; The Pharmacological Basis of Therapeutics
C Max 27.0 ng/ml 27±5.9 ng/ml PO, oral; poor metabolizers, PM; The Pharmacological Basis of Therapeutics
T Max 1.1 h 0.83-1.33 h Liquid; DRUGBANK
T Max 15.0 h 14-16 h Tablet, PO, oral; extended release formulation; DRUGBANK
T Max 0.72 h 0.72±0.46 h PO, oral; extensive metabolizers, EM; The Pharmacological Basis of Therapeutics
T Max 0.93 h 0.93±0.59 h PO, oral; poor metabolizers, PM; The Pharmacological Basis of Therapeutics
Clearance 83.0 L/h 83.0 L/h apparent clearance; DRUGBANK
Clearance 41.7 L/h 24.5-58.8 L/h DRUGBANK
Clearance 0.67 L/h/kg 11.1±3.57 ml/min/kg apparent clearance; PO, oral; extensive metabolizers, EM; The Pharmacological Basis of Therapeutics
Clearance 0.39 L/h/kg 6.54±1.25 ml/min/kg apparent clearance; PO, oral; poor metabolizers, PM; The Pharmacological Basis of Therapeutics
Volume of Distribution 402.0 L 402.0 L Apparent volume of distribution; DRUGBANK
Half-life 8.0 h 7-9 h elimination half-life; DRUGBANK
Half-life 4.2 h 4.24±0.99 h extensive metabolizers, EM; PO, oral; The Pharmacological Basis of Therapeutics
Half-life 6.2 h 6.16±1.97 h poor metabolizers, PM; PO, oral; The Pharmacological Basis of Therapeutics
Toxicity LD50 85.7 mg/kg 85.7 mg/kg subcutaneous injection, SC; parenteral administration; mouse; T3DB
Eliminate Route 10.2 % 10.2±1.8 % Urinary excretion; normal,healthy; extensive metabolizers, EM; human, homo sapiens; Unchanged drug; The Pharmacological Basis of Therapeutics
Eliminate Route 18.1 % 18.1±4.5 % Urinary excretion; normal,healthy; poor metabolizers, PM; human, homo sapiens; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 36.0 % 36 % plasma proteins; DRUGBANK

Maximum Dosage

Not Available

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1