Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00953 ...
Drug Name Rizatriptan
Molecular Weight 269.3449
Molecular Formula C15H19N5
CAS Number 144034-80-0
SMILES CN(C)CCC1=CNC2=C1C=C(CN1C=NC=N1)C=C2
External Links
DRUGBANK DB00953
T3DB T3D2940
PubChem Compound 5078
PDR 364
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 1.4 - 1.4 - DRUGBANK
Melting Point 179.0 ℃ 178-180 ℃ DRUGBANK
Water Solubility 42000.0 mg/L 42 mg/ml DRUGBANK

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
Bioavailability 45.0 % 45 % PO, oral; DRUGBANK
Bioavailability 47.0 % 47.0 % PO, oral; The Pharmacological Basis of Therapeutics
C Max 20.0 ng/ml 20±4.9 ng/ml Oral single dose; adults; normal,healthy; The Pharmacological Basis of Therapeutics
C Max 37.0 ng/ml 37±13 ng/ml Oral multiple dose; adults; normal,healthy; The Pharmacological Basis of Therapeutics
T Max 0.90 h 0.9±0.4 h Oral single dose; adults; normal,healthy; The Pharmacological Basis of Therapeutics
T Max 4.8 h 4.8±0.7 h Oral multiple dose; adults; normal,healthy; The Pharmacological Basis of Therapeutics
Clearance 0.74 L/h/kg 12.3±1.4 ml/min/kg normal,healthy; adults; Male, men; The Pharmacological Basis of Therapeutics
Clearance 1.1 L/h/kg 18.9±2.8 ml/min/kg normal,healthy; adults; Male, men; hepatopathy，LD ↓ ;RD, renal impairment, Renal disease，including uremia ↓ ; The Pharmacological Basis of Therapeutics
Clearance 0.96 L/h/kg 16 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 140.0 L 140.0 L Male, men; DRUGBANK
Volume of Distribution 110.0 L 110.0 L  Female, women; DRUGBANK
Volume of Distribution 1.5 L/kg 1.5±0.2 L/kg normal,healthy; adults; Male, men; The Pharmacological Basis of Therapeutics
Volume of Distribution 2.2 L/kg 2.2±0.4 L/kg normal,healthy; adults; Male, men; The Pharmacological Basis of Therapeutics
Volume of Distribution 1.9 L/kg 1.9 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 2.5 h 2-3 h DRUGBANK
Half-life 2.2 h 2.2 h normal,healthy; adults; Male, men; The Pharmacological Basis of Therapeutics
Half-life 2.4 h 2.4 h normal,healthy; adults;  Female, women; The Pharmacological Basis of Therapeutics
Half-life 2.2 h 2.2 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Eliminate Route 14.0 % ~14 % Urinary excretion; PO, oral; Unchanged drug; DRUGBANK
Eliminate Route 28.0 % 28±9 % Urinary excretion; adults;  Female, women; normal,healthy; human, homo sapiens; Unchanged drug; The Pharmacological Basis of Therapeutics
Eliminate Route 29.0 % 29 % Urinary excretion; adults; Male, men; normal,healthy; human, homo sapiens; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 14.0 % 14 % DRUGBANK
Protein Binding 14.0 % 14 % adults; normal,healthy; human, homo sapiens; The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Frequency Brand Name Component Reference
Max dose for children 10.0 mg 10 mg PO, oral qd Maxalt rizatriptan benzoate PDR
Max dose for children 5.0 mg 5 mg PO, oral qd Maxalt rizatriptan benzoate PDR
Max dose for children 5.0 mg 5 mg PO, oral qd Maxalt rizatriptan benzoate PDR
Max dose for adolescents 10.0 mg 10 mg PO, oral qd Maxalt rizatriptan benzoate PDR
Max dose for adolescents 5.0 mg 5 mg PO, oral qd Maxalt rizatriptan benzoate PDR
Max dose for adolescents 5.0 mg 5 mg PO, oral qd Maxalt rizatriptan benzoate PDR
Max dose for adults 30.0 mg/day 30 mg/day PO, oral qd Maxalt rizatriptan benzoate PDR
Max dose for adults 15.0 mg/day 15 mg/day PO, oral Maxalt rizatriptan benzoate PDR
Max dose for geriatric 30.0 mg/day 30 mg/day PO, oral qd Maxalt rizatriptan benzoate PDR
Max dose for geriatric 15.0 mg/day 15 mg/day PO, oral Maxalt rizatriptan benzoate PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1