Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00951 ...
Drug Name Isoniazid
Molecular Weight 137.1393
Molecular Formula C6H7N3O
CAS Number 54-85-3
SMILES NNC(=O)C1=CC=NC=C1
External Links
DRUGBANK DB00951
T3DB T3D4777
PubChem Compound 3767
PDR 3885
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P -0.7 - -0.7 - HANSCH,C ET AL. (1995)
Melting Point 171.4 ℃ 171.4 ℃ PhysProp
Water Solubility 140000.0 mg/L 140000 mg/L MERCK INDEX 2001)
pKa 1.82 - 1.82 - PERRIN,DD (1965)
Log S 0.01 - 0.01 - ADME Research, USCD

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
C Max 5400.0 ng/ml 5.4±2.0 mcg/ml PO, oral; Drug form; normal,healthy; The Pharmacological Basis of Therapeutics
C Max 7100.0 ng/ml 7.1±1.9 mcg/ml PO, oral; Drug form; normal,healthy; The Pharmacological Basis of Therapeutics
T Max 1.1 h 1.1±0.5 h PO, oral; Drug form; normal,healthy; The Pharmacological Basis of Therapeutics
T Max 1.1 h 1.1±0.6 h PO, oral; Drug form; normal,healthy; The Pharmacological Basis of Therapeutics
Clearance 0.44 L/h/kg 7.4±2.0 ml/min/kg extensive metabolizers, EM; Elderly → ;RD, renal impairment, Renal disease，including uremia ↓ ; The Pharmacological Basis of Therapeutics
Clearance 0.22 L/h/kg 3.7±1.1 ml/min/kg poor metabolizers, PM; Elderly → ;RD, renal impairment, Renal disease，including uremia ↓ ; The Pharmacological Basis of Therapeutics
Volume of Distribution 0.67 L/kg 0.67±0.15 L/kg extensive metabolizers, EM; Elderly → ;RD, renal impairment, Renal disease，including uremia → ; The Pharmacological Basis of Therapeutics
Half-life 1.1 h 0.5-1.6 h fast acetylators; DRUGBANK
Half-life 3.5 h 2-5 h Slow acetylators; DRUGBANK
Half-life 1.1 h 1.1±0.1 h fast acetylators; Neonates ↑ ;Children → ;acute viral hepatitis AVH ↑ ;Hepatic cirrhosis, cirr ↑ ;RD, renal impairment, Renal disease，including uremia ↑ ;Obesity → ;hyperthyroid, HTh → ;Age → ; The Pharmacological Basis of Therapeutics
Half-life 3.1 h 3.1±1.1 h Slow acetylators; Neonates ↑ ;Children → ;acute viral hepatitis AVH ↑ ;Hepatic cirrhosis, cirr ↑ ;RD, renal impairment, Renal disease，including uremia ↑ ;Obesity → ;hyperthyroid, HTh → ;Age → ; The Pharmacological Basis of Therapeutics
Toxicity LD50 100.0 mg/kg 100.0 mg/kg PO, oral; human, homo sapiens; DRUGBANK
Toxicity LD50 100.0 mg/kg 100.0 mg/kg PO, oral; mouse; T3DB
Eliminate Route 60.0 % 50-70 % Urinary excretion; DRUGBANK
Eliminate Route 7.0 % 7±2 % Urinary excretion; fast acetylators; Unchanged drug; The Pharmacological Basis of Therapeutics
Eliminate Route 29.0 % 29±5 % Urinary excretion; Slow acetylators; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 5.0 % 0-10 % DRUGBANK
Protein Binding 0 % ~0 % The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Frequency Brand Name Component Reference
Max dose for infants 300.0 mg/day 300 mg/day PO, oral;IM,intramuscular injection; qd Isoniazid Solution isoniazid PDR
Max dose for infants 900.0 mg/day 900 mg/day PO, oral;IM,intramuscular injection; biw Isoniazid Solution isoniazid PDR
Max dose for children 300.0 mg/day 300 mg/day PO, oral;IM,intramuscular injection; qd Isoniazid Solution isoniazid PDR
Max dose for children 900.0 mg/day 900 mg/day PO, oral;IM,intramuscular injection; biw Isoniazid Solution isoniazid PDR
Max dose for adolescents 300.0 mg/day 300 mg/day PO, oral;IM,intramuscular injection; qd Isoniazid Solution isoniazid PDR
Max dose for adolescents 900.0 mg/day 900 mg/day PO, oral;IM,intramuscular injection; biw Isoniazid Solution isoniazid PDR
Max dose for adults 300.0 mg/day 300 mg/day PO, oral;IM,intramuscular injection; qd Isoniazid Solution isoniazid PDR
Max dose for adults 900.0 mg/day 900 mg/day PO, oral;IM,intramuscular injection; biw Isoniazid Solution isoniazid PDR
Max dose for elderly 300.0 mg/day 300 mg/day PO, oral;IM,intramuscular injection; qd Isoniazid Solution isoniazid PDR
Max dose for elderly 900.0 mg/day 900 mg/day PO, oral;IM,intramuscular injection; biw Isoniazid Solution isoniazid PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1