Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00947 ...
Drug Name Fulvestrant
Molecular Weight 606.78
Molecular Formula C32H47F5O3S
CAS Number 129453-61-8
SMILES [H][C@@]12CC[C@H](O)[C@@]1(C)CC[C@]1([H])C3=CC=C(O)C=C3C[C@@H](CCCCCCCCCS(=O)CCCC(F)(F)C(F)(F)F)[C@@]21[H]
External Links
DRUGBANK DB00947
T3DB T3D4757
PubChem Compound 17756771
PDR 2212
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 8.9 - 8.9 - DRUGBANK

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
C Max 8.2 ng/ml 8.2±5.2 ng/ml IM,intramuscular injection; postmenopausal women; breast cancer; The Pharmacological Basis of Therapeutics
T Max 167.0 h 167.0 h IM,intramuscular injection; postmenopausal women; breast cancer; The Pharmacological Basis of Therapeutics
Clearance 0.71 L/h/kg 9.3-14.3 ml/min/kg The Pharmacological Basis of Therapeutics
Clearance 0.71 L/h/kg 11.8 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 4.0 L/kg 3.0-5 L/kg DRUGBANK
Volume of Distribution 4.2 L/kg 3.0-5.3 L/kg The Pharmacological Basis of Therapeutics
Volume of Distribution 4.2 L/kg 4.15 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 960.0 h 40 day DRUGBANK
Half-life 16.5 h 14-19 h elimination half-life; intravenous injection, IV; The Pharmacological Basis of Therapeutics
Half-life 960.0 h ~40 day IM,intramuscular injection; The Pharmacological Basis of Therapeutics
Half-life 16.0 h 16 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Eliminate Route 90.0 % ~90 % Faeces excretion; DRUGBANK
Eliminate Route 1.0 % <1 % Urinary excretion; DRUGBANK
Eliminate Route 1.0 % <1 % Urinary excretion; human, homo sapiens; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 99.0 % 99 % DRUGBANK
Protein Binding 99.0 % 99 % human, homo sapiens; The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for adults 500.0 mg 500 mg IM,intramuscular injection Faslodex fulvestrant PDR
Max dose for elderly 500.0 mg 500 mg IM,intramuscular injection Faslodex fulvestrant PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1