Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00943 ...
Drug Name Zalcitabine
Molecular Weight 211.2178
Molecular Formula C9H13N3O3
CAS Number 7481-89-2
SMILES NC1=NC(=O)N(C=C1)[C@H]1CC[C@@H](CO)O1
External Links
DRUGBANK DB00943
T3DB T3D4719
PubChem Compound 24066
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P -1.3 - -1.3 - SANGSTER (1993)
Melting Point 217.5 ℃ 217-218 ℃ PhysProp
Water Solubility 76400.0 mg/L 76400 mg/L PHYSICIANS DESK REFERENCE 2001)

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
Bioavailability 80.0 % >80 % PO, oral; DRUGBANK
Metabolic 0 % ~0 % Liver metabolism; DRUGBANK
Clearance 17.1 L/h 285.0 ml/min intravenous injection, IV; AIDS,HIV; patients; DRUGBANK
Clearance 0.34 L/h/kg 5.6 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 0.52 L/kg 0.304-0.734 L/kg DRUGBANK
Volume of Distribution 0.54 L/kg 0.54 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 2.0 h 2 h DRUGBANK
Half-life 1.2 h 1.2 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Eliminate Route 80.0 % ~80 % Urinary excretion; intravenous injection, IV; DRUGBANK
Eliminate Route 60.0 % ~60 % Urinary excretion; PO, oral; DRUGBANK
Protein Binding 4.0 % <4 % DRUGBANK

Maximum Dosage

Not Available

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1