Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00939 ...
Drug Name Meclofenamic acid
Molecular Weight 296.149
Molecular Formula C14H11Cl2NO2
CAS Number 644-62-2
SMILES CC1=C(Cl)C(NC2=CC=CC=C2C(O)=O)=C(Cl)C=C1
External Links
DRUGBANK DB00939
PubChem Compound 4037
PDR 1796

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 5.0 - 5.0 - DRUGBANK
Melting Point 249.0 ℃ 248-250 ℃ U.S. Patent 3,313,848.
Water Solubility 30.0 mg/L 30 mg/L MERCK INDEX 1996)

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
T Max 1.3 h 0.5-2 h PO, oral; DRUGBANK
T Max 3.0 h 3 h PO, oral; food; food ↑ ; DRUGBANK
Clearance 12.4 L/h 206.0 ml/min PO, oral; DRUGBANK
Volume of Distribution 26.2 L 9.1-43.2 L DRUGBANK
Half-life 3.1 h 0.8-5.3 h elimination half-life; Oral single dose; normal,healthy; DRUGBANK
Half-life 15.0 h 15 h DRUGBANK
Protein Binding 99.0 % >99 % plasma proteins; DRUGBANK

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for adolescents 400.0 mg/day 400 mg/day PO, oral Meclofenamate Sodium meclofenamate sodium PDR
Max dose for adults 400.0 mg/day 400 mg/day PO, oral Meclofenamate Sodium meclofenamate sodium PDR
Max dose for elderly 400.0 mg/day 400 mg/day PO, oral Meclofenamate Sodium meclofenamate sodium PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1