Basic Information
| Drug ID | DDPD00934 |
|
| Drug Name | Maprotiline | |
| Molecular Weight | 277.4033 | |
| Molecular Formula | C20H23N | |
| CAS Number | 10262-69-8 | |
| SMILES | CNCCCC12CCC(C3=CC=CC=C13)C1=CC=CC=C21 | |
| External Links | ||
| DRUGBANK | DB00934 | |
| T3DB | T3D2934 | |
| PubChem Compound | 4011 | |
| PDR | 1795 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 5.1 | - | 5.1 | - | DRUGBANK |
| Melting Point | 93.0 | ℃ | 93 | ℃ | PhysProp |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Absorption | 100.0 | % | 100 | % | PO, oral; | DRUGBANK |
| Clearance | 0.84 | L/h/kg | 14 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 45.0 | L/kg | 45 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 51.0 | h | ~51(27-58) | h | DRUGBANK | Half-life | 51.0 | h | 51 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Toxicity LD50 | 900.0 | mg/kg | ~900 | mg/kg | PO, oral; Rattus, Rat; | DRUGBANK | Toxicity LD50 | 90.0 | mg/kg | 90.0 | mg/kg | PO, oral; Female, women; | DRUGBANK | Toxicity LD50 | 900.0 | mg/kg | 900.0 | mg/kg | PO, oral; Rattus, Rat; | T3DB | Toxicity LD50 | 90.0 | mg/kg | 90.0 | mg/kg | PO, oral; human, homo sapiens; | T3DB |
| Eliminate Route | 60.0 | % | ~60 | % | Urinary excretion; Oral single dose; | DRUGBANK | Eliminate Route | 30.0 | % | 30 | % | Faeces excretion; Oral single dose; | DRUGBANK |
| Protein Binding | 88.0 | % | 88 | % | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for adults | 225.0 | mg/day | 225 | mg/day | PO, oral | Maprotiline Hydrochloride | maprotiline hydrochloride | PDR |
| Max dose for geriatric | 225.0 | mg/day | 225 | mg/day | PO, oral | Maprotiline Hydrochloride | maprotiline hydrochloride | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1