Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00929 ...
Drug Name Misoprostol
Molecular Weight 382.5341
Molecular Formula C22H38O5
CAS Number 59122-46-2
SMILES CCCCC(C)(O)C\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC
External Links
DRUGBANK DB00929
PubChem Compound 5282381
PDR 1044
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Melting Point 262.0 ℃ 261-263 ℃ http://www.chemspider.com/Chemical-Structure.4445541.html
Water Solubility 1600.0 mg/L 1.6 mg/ml https://www.caymanchem.com/pdfs/13820.pdf

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
AUC 2.0 ng.h/ml 2.0192±0.8032 ng.h/ml PO, oral; DRUGBANK
AUC 3.2 ng.h/ml 3.2094±1.0417 ng.h/ml sublingual; DRUGBANK
AUC 2.1 ng.h/ml 2.0726±0.3578 ng.h/ml buccal; DRUGBANK
C Max 2.7 ng/ml 2.6830±1.2161 ng/ml PO, oral; DRUGBANK
C Max 2.4 ng/ml 2.4391±1.1567 ng/ml sublingual; DRUGBANK
C Max 1.4 ng/ml 1.3611±0.3436 ng/ml buccal; DRUGBANK
T Max 0.35 h 0.345±0.186 h PO, oral; DRUGBANK
T Max 0.71 h 0.712±0.415 h sublingual; DRUGBANK
T Max 1.3 h 1.308±0.624 h buccal; DRUGBANK
Clearance 17.2 L/h/kg 0.286 L/kg/min Total clearance; DRUGBANK
Clearance 13.6 L/h/kg 0.226±0.073 L/kg/min Total clearance; mild renal function; DRUGBANK
Clearance 16.2 L/h/kg 0.270±0.103 L/kg/min Total clearance; moderate renal function; DRUGBANK
Clearance 6.3 L/h/kg 0.105±0.052 L/kg/min Total clearance; severe renal function; DRUGBANK
Volume of Distribution 13.6 L/kg 13.6±8.0 L/kg normal renal function; DRUGBANK
Volume of Distribution 17.3 L/kg 17.3±23.0 L/kg mild renal function; DRUGBANK
Volume of Distribution 14.3 L/kg 14.3±6.8 L/kg moderate renal function; DRUGBANK
Volume of Distribution 11.0 L/kg 11.0±9.6 L/kg severe renal function; DRUGBANK
Half-life 1.0 h 1.0401±0.5090 h PO, oral; DRUGBANK
Half-life 0.85 h 0.8542±0.1170 h sublingual; DRUGBANK
Half-life 0.84 h 0.8365±0.1346 h buccal; DRUGBANK
Toxicity LD50 81.0 mg/kg 81.0 mg/kg PO, oral; Rattus, Rat; DRUGBANK
Toxicity LD50 27.0 mg/kg 27.0 mg/kg PO, oral; mouse; DRUGBANK
Toxicity LD50 40.0 mg/kg 40.0 mg/kg Intraperitoneal, IP; Rattus, Rat; DRUGBANK
Toxicity LD50 70.0 mg/kg 70.0 mg/kg Intraperitoneal, IP; mouse; DRUGBANK
Eliminate Route 73.2 % 73.2±4.6 % Urinary excretion; PO, oral; DRUGBANK
Protein Binding 90.0 % <90 % DRUGBANK

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for adults 0.8 mg/day 800 mcg/day PO, oral Cytotec misoprostol PDR
Max dose for elderly 0.8 mg/day 800 mcg/day PO, oral Cytotec misoprostol PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1