Basic Information
| Drug ID | DDPD00928 |
|
| Drug Name | Azacitidine | |
| Molecular Weight | 244.2047 | |
| Molecular Formula | C8H12N4O5 | |
| CAS Number | 320-67-2 | |
| SMILES | NC1=NC(=O)N(C=N1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O | |
| External Links | ||
| DRUGBANK | DB00928 | |
| T3DB | T3D4676 | |
| PubChem Compound | 9444 | |
| PDR | 1664 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | -3.5 | - | -3.5 | - | DRUGBANK |
| Melting Point | 229.0 | ℃ | 229 | ℃ | PhysProp |
| Water Solubility | 89000.0 | mg/L | 89000 | mg/L | DRUGBANK |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Bioavailability | 89.0 | % | 89 | % | subcutaneous injection, SC; | DRUGBANK |
| Clearance | 167.0 | L/h | 167±49 | L/h | DRUGBANK | |
| Volume of Distribution | 76.0 | L | 76±26 | L | DRUGBANK | |
| Half-life | 4.0 | h | ~4 | h | elimination half-life; | DRUGBANK |
| Eliminate Route | 85.0 | % | 85 | % | Urinary excretion; intravenous injection, IV; tumor; | DRUGBANK | Eliminate Route | 1.0 | % | <1 | % | Faeces excretion; intravenous injection, IV; tumor; | DRUGBANK | Eliminate Route | 0.50 | % | 0.5 | % | Urinary excretion; subcutaneous injection, SC; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Frequency | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|---|
| Max dose for adults | 100.0 | mg/m2/day | 100 | mg/m2/day | qd | Vidaza | azacitidine | PDR | |
| Max dose for geriatric | 100.0 | mg/m2/day | 100 | mg/m2/day | qd | Vidaza | azacitidine | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1