Basic Information
| Drug ID | DDPD00927 |
|
| Drug Name | Famotidine | |
| Molecular Weight | 337.445 | |
| Molecular Formula | C8H15N7O2S3 | |
| CAS Number | 76824-35-6 | |
| SMILES | NC(N)=NC1=NC(CSCCC(N)=NS(N)(=O)=O)=CS1 | |
| External Links | ||
| DRUGBANK | DB00927 | |
| PubChem Compound | 3325 | |
| PDR | 1143 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | -0.64 | - | -0.64 | - | ISLAM,MS & NARURKAR,MM (1993) |
| Melting Point | 163.5 | ℃ | 163.5 | ℃ | PhysProp |
| Water Solubility | 1000.0 | mg/L | 1000 | mg/L | MERCK INDEX 1996) |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Factor | Reference |
|---|---|---|---|---|---|---|---|
| Bioavailability | 45.0 | % | 40-50 | % | PO, oral; | DRUGBANK | |
| T Max | 2.5 | h | 1-4 | h | PO, oral; | DRUGBANK | |
| Metabolic | 27.5 | % | 25-30 | % | Liver metabolism; | DRUGBANK | |
| Clearance | 21.0 | L/h | 250-450 | ml/min | Renal clearance; | DRUGBANK | Clearance | 0.40 | L/h/kg | 6.6 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 1.2 | L/kg | 1-1.3 | L/kg | Steady state volume of distribution; | DRUGBANK | Volume of Distribution | 1.2 | L/kg | 1.2 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 3.0 | h | ~2-4 | h | elimination half-life; | RD, renal impairment, Renal disease，including uremia ↑ ; | DRUGBANK | Half-life | 2.8 | h | 2.8 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Toxicity LD50 | 4049.0 | mg/kg | 4049.0 | mg/kg | PO, oral; Rattus, Rat; | DRUGBANK | Toxicity LD50 | 4686.0 | mg/kg | 4686.0 | mg/kg | PO, oral; mouse; | DRUGBANK | Toxicity LD50 | 800.0 | mg/kg | 800.0 | mg/kg | intravenous injection, IV; mouse; Rattus, Rat; | DRUGBANK |
| Toxicity TDLo | 0.57 | mg/kg/day | 4.0 | mg/kg/7D | PO, oral; Male, men; | DRUGBANK | |
| Eliminate Route | 67.5 | % | ~65-70 | % | Urinary excretion; | DRUGBANK | Eliminate Route | 70.0 | % | ~70 | % | Urinary excretion; intravenous injection, IV; Unchanged drug; | DRUGBANK |
| Protein Binding | 17.5 | % | 15-20 | % | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for neonates | 1.0 | mg/kg/day | 1 | mg/kg/day | PO, oral | Famotidine Injection | famotidine | PDR |
| Max dose for neonates | 0.5 | mg/kg/day | 0.5 | mg/kg/day | intravenous injection, IV | Famotidine Injection | famotidine | PDR |
| Max dose for infants | 2.0 | mg/kg/day | 2 | mg/kg/day | PO, oral | Famotidine Injection | famotidine | PDR |
| Max dose for infants | 2.0 | mg/kg/day | 2 | mg/kg/day | intravenous injection, IV | Famotidine Injection | famotidine | PDR |
| Max dose for infants | 1.0 | mg/kg/day | 1 | mg/kg/day | PO, oral | Famotidine Injection | famotidine | PDR |
| Max dose for infants | 2.0 | mg/kg/day | 2 | mg/kg/day | intravenous injection, IV | Famotidine Injection | famotidine | PDR |
| Max dose for children | 1.0 | mg/kg/day | 1 | mg/kg/day | PO, oral | Famotidine Injection | famotidine | PDR |
| Max dose for children | 80.0 | mg/day | 80 | mg/day | PO, oral | Famotidine Injection | famotidine | PDR |
| Max dose for children | 1.0 | mg/kg/day | 1 | mg/kg/day | intravenous injection, IV | Famotidine Injection | famotidine | PDR |
| Max dose for children | 40.0 | mg/day | 40 | mg/day | intravenous injection, IV | Famotidine Injection | famotidine | PDR |
| Max dose for children | 2.0 | mg/kg/day | 2 | mg/kg/day | intravenous injection, IV | Famotidine Injection | famotidine | PDR |
| Max dose for adolescents | 1.0 | mg/kg/day | 1 | mg/kg/day | PO, oral | Famotidine Injection | famotidine | PDR |
| Max dose for adolescents | 80.0 | mg/day | 80 | mg/day | PO, oral | Famotidine Injection | famotidine | PDR |
| Max dose for adolescents | 1.0 | mg/kg/day | 1 | mg/kg/day | intravenous injection, IV | Famotidine Injection | famotidine | PDR |
| Max dose for adolescents | 40.0 | mg/day | 40 | mg/day | intravenous injection, IV | Famotidine Injection | famotidine | PDR |
| Max dose for adolescents | 2.0 | mg/kg/day | 2 | mg/kg/day | intravenous injection, IV | Famotidine Injection | famotidine | PDR |
| Max dose for adults | 40.0 | mg/day | 40 | mg/day | PO, oral;intravenous injection, IV; | Famotidine Injection | famotidine | PDR |
| Max dose for adults | 20.0 | mg/day | 20 | mg/day | PO, oral | Famotidine Injection | famotidine | PDR |
| Max dose for adults | 40.0 | mg/day | 40 | mg/day | PO, oral | Famotidine Injection | famotidine | PDR |
| Max dose for adults | 80.0 | mg/day | 80 | mg/day | PO, oral | Famotidine Injection | famotidine | PDR |
| Max dose for adults | 640.0 | mg/day | 640 | mg/day | PO, oral | Famotidine Injection | famotidine | PDR |
| Max dose for adults | 80.0 | mg/day | 80 | mg/day | intravenous injection, IV | Famotidine Injection | famotidine | PDR |
| Max dose for adults | 40.0 | mg/day | 40 | mg/day | PO, oral | Famotidine Injection | famotidine | PDR |
| Max dose for geriatric | 40.0 | mg/day | 40 | mg/day | PO, oral;intravenous injection, IV; | Famotidine Injection | famotidine | PDR |
| Max dose for geriatric | 20.0 | mg/day | 20 | mg/day | PO, oral | Famotidine Injection | famotidine | PDR |
| Max dose for geriatric | 40.0 | mg/day | 40 | mg/day | PO, oral | Famotidine Injection | famotidine | PDR |
| Max dose for geriatric | 80.0 | mg/day | 80 | mg/day | PO, oral | Famotidine Injection | famotidine | PDR |
| Max dose for geriatric | 640.0 | mg/day | 640 | mg/day | PO, oral | Famotidine Injection | famotidine | PDR |
| Max dose for geriatric | 80.0 | mg/day | 80 | mg/day | intravenous injection, IV | Famotidine Injection | famotidine | PDR |
| Max dose for geriatric | 40.0 | mg/day | 40 | mg/day | PO, oral | Famotidine Injection | famotidine | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1