Basic Information
| Drug ID | DDPD00924 |
|
| Drug Name | Cyclobenzaprine | |
| Molecular Weight | 275.3874 | |
| Molecular Formula | C20H21N | |
| CAS Number | 303-53-7 | |
| SMILES | CN(C)CCC=C1C2=CC=CC=C2C=CC2=CC=CC=C12 | |
| External Links | ||
| DRUGBANK | DB00924 | |
| PubChem Compound | 2895 | |
| PDR | 2329 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 5.2 | - | 5.2 | - | DRUGBANK |
| Melting Point | 217.0 | ℃ | 217 | ℃ | FDA Label |
| pKa | 8.47 | - | 8.47 | - | FDA Label |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| AUC | 177.0 | ng.h/ml | 177.0 | ng.h/ml | PO, oral; | DRUGBANK |
| Bioavailability | 44.0 | % | 33-55 | % | PO, oral; | DRUGBANK |
| C Max | 20.0 | ng/ml | 5-35 | ng/ml | PO, oral; | DRUGBANK |
| T Max | 4.0 | h | 4 | h | PO, oral; | DRUGBANK |
| Clearance | 42.0 | L/h | ~0.7 | L/min | Plasma clearance; | DRUGBANK |
| Volume of Distribution | 146.0 | L | ~146 | L | DRUGBANK | |
| Half-life | 18.0 | h | ~18 | h | effective half-life; normal,healthy; young; | DRUGBANK | Half-life | 33.4 | h | 33.4 | h | Elderly; | DRUGBANK | Half-life | 46.2 | h | 46.2 | h | effective half-life; hepatic insufficiency; | DRUGBANK |
| Toxicity LD50 | 338.0 | mg/kg | 338.0 | mg/kg | PO, oral; mouse; | DRUGBANK | Toxicity LD50 | 425.0 | mg/kg | 425.0 | mg/kg | PO, oral; Rattus, Rat; | DRUGBANK |
| Eliminate Route | 44.5 | % | 38-51 | % | Urinary excretion; | DRUGBANK | Eliminate Route | 14.5 | % | 14-15 | % | Faeces excretion; | DRUGBANK | Eliminate Route | 1.0 | % | ~1 | % | Urinary excretion; Unchanged drug; | DRUGBANK |
| Protein Binding | 93.0 | % | ~93 | % | plasma proteins; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for adolescents | 30.0 | mg/day | 30 | mg/day | Tablet,PO，oral | Amrix | cyclobenzaprine hydrochloride | PDR |
| Max dose for adults | 30.0 | mg/day | 30 | mg/day | PO, oral | Amrix | cyclobenzaprine hydrochloride | PDR |
| Max dose for geriatric | 30.0 | mg/day | 30 | mg/day | PO, oral | Amrix | cyclobenzaprine hydrochloride | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1