Basic Information
| Drug ID | DDPD00920 |
|
| Drug Name | Ketotifen | |
| Molecular Weight | 309.425 | |
| Molecular Formula | C19H19NOS | |
| CAS Number | 34580-13-7 | |
| SMILES | CN1CCC(CC1)=C1C2=C(SC=C2)C(=O)CC2=CC=CC=C12 | |
| External Links | ||
| DRUGBANK | DB00920 | |
| PubChem Compound | 3827 | |
| PDR | 2661 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 2.2 | - | 2.2 | - | DRUGBANK |
| Melting Point | 152.5 | ℃ | 152-153 | ℃ | U.S. Patents 3,682,930; 3,770,728; and 3,960,894 |
| pKa | 8.43 | - | 8.43 | - | DRUGBANK |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Absorption | 60.0 | % | >60 | % | PO, oral; | DRUGBANK |
| Half-life | 21.0 | h | 21 | h | elimination half-life; | DRUGBANK |
| Protein Binding | 75.0 | % | 75 | % | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for children | 3.0 | drop/day | 3 | drop/day | ophthalmic administration | Zaditor | ketotifen fumarate | PDR |
| Max dose for adolescents | 3.0 | drop/day | 3 | drop/day | ophthalmic administration | Zaditor | ketotifen fumarate | PDR |
| Max dose for adults | 3.0 | drop/day | 3 | drop/day | ophthalmic administration | Zaditor | ketotifen fumarate | PDR |
| Max dose for elderly | 3.0 | drop/day | 3 | drop/day | ophthalmic administration | Zaditor | ketotifen fumarate | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1