DETAILS

Property Name	Property Value	Unit	Raw Value	Raw Unit	Reference
Log P	0.5	-	0.5	-	DRUGBANK
Melting Point	162.0	℃	161-163	℃	DRUGBANK
Water Solubility	800.0	mg/L	0.8	mg/ml	DRUGBANK
pKa	10.2	-	10.2	-	DRUGBANK

Property Name	Property Value	Unit	Raw Value	Raw Unit	Annotation	Factor	Reference
C Max	28000.0	ng/ml	28±4	mcg/ml	PO, oral; adults; normal,healthy;		The Pharmacological Basis of Therapeutics
T Max	3.4	h	2.8-3.9	h	PO, oral; food;	food → ;	DRUGBANK
T Max	1.8	h	1.8±0.4	h	PO, oral; adults; normal,healthy;		The Pharmacological Basis of Therapeutics
Clearance	0.0195	L/h/kg	0.3-0.35	ml/min/kg	patients;		DRUGBANK
Clearance	0.0255	L/h/kg	0.35-0.5	ml/min/kg	Drug combination;		DRUGBANK
Clearance	0.007800	L/h/kg	0.13	ml/min/kg			The Pharmacological Basis of Therapeutics
Volume of Distribution	1.5	L/kg	1.45	L/kg			DRUGBANK
Volume of Distribution	1.5	L/kg	1.2-1.8	L/kg			The Pharmacological Basis of Therapeutics
Half-life	63.0	h	63	h			DRUGBANK
Half-life	63.0	h	63±14	h			The Pharmacological Basis of Therapeutics
Eliminate Route	38.5	%	29-48	%	Urinary excretion; PO, oral; Unchanged drug;		The Pharmacological Basis of Therapeutics
Protein Binding	40.0	%	40	%			DRUGBANK
Protein Binding	39.0	%	38-40	%			The Pharmacological Basis of Therapeutics

Property Name	Property Value	Unit	Raw Value	Raw Unit	Annotation	Brand Name	Component	Reference
Max dose for children	12.0	mg/kg/day	12	mg/kg/day	PO, oral	Zonegran	zonisamide	PDR
Max dose for adolescents	600.0	mg/day	600	mg/day	PO, oral	Zonegran	zonisamide	PDR
Max dose for adolescents	12.0	mg/kg/day	12	mg/kg/day	PO, oral	Zonegran	zonisamide	PDR
Max dose for adults	600.0	mg/day	600	mg/day	PO, oral	Zonegran	zonisamide	PDR
Max dose for elderly	600.0	mg/day	600	mg/day	PO, oral	Zonegran	zonisamide	PDR

Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1