Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00903 ...
Drug Name Etacrynic acid
Molecular Weight 303.138
Molecular Formula C13H12Cl2O4
CAS Number 58-54-8
SMILES CCC(=C)C(=O)C1=C(Cl)C(Cl)=C(OCC(O)=O)C=C1
External Links
DRUGBANK DB00903
PubChem Compound 3278
PDR 2065
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 3.3 - 3.3 - DRUGBANK
Melting Point 119.5 ℃ 118.5-120.5 ℃ Schultz, E.M. and Sprague, J.M.; U.S. Patent 3,255,241; June 7, 1966; assigned to Merck & co., Inc.
pKa 3.5 - 3.5 - MERCK INDEX (2001)

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
Protein Binding 98.0 % >98 % DRUGBANK

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for infants 0.0 0 Edecrin/Sodium Edecrin (ethacrynate sodium); (ethacrynic acid) PDR
Max dose for children 3.0 mg/kg/day 3 mg/kg/day PO, oral Edecrin/Sodium Edecrin (ethacrynate sodium); (ethacrynic acid) PDR
Max dose for children 1.0 mg/kg/day 1 mg/kg/day intravenous injection, IV Edecrin/Sodium Edecrin (ethacrynate sodium); (ethacrynic acid) PDR
Max dose for adolescents 3.0 mg/kg/day 3 mg/kg/day PO, oral Edecrin/Sodium Edecrin (ethacrynate sodium); (ethacrynic acid) PDR
Max dose for adolescents 1.0 mg/kg/day 1 mg/kg/day intravenous injection, IV Edecrin/Sodium Edecrin (ethacrynate sodium); (ethacrynic acid) PDR
Max dose for adults 400.0 mg/day 400 mg/day PO, oral Edecrin/Sodium Edecrin (ethacrynate sodium); (ethacrynic acid) PDR
Max dose for adults 100.0 mg/dose 100 mg/dose intravenous injection, IV Edecrin/Sodium Edecrin (ethacrynate sodium); (ethacrynic acid) PDR
Max dose for geriatric 400.0 mg/day 400 mg/day PO, oral Edecrin/Sodium Edecrin (ethacrynate sodium); (ethacrynic acid) PDR
Max dose for geriatric 100.0 mg/dose 100 mg/dose intravenous injection, IV Edecrin/Sodium Edecrin (ethacrynate sodium); (ethacrynic acid) PDR

Drug Property Radar Chart

...

Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1