Basic Information
| Drug ID | DDPD00899 |
|
| Drug Name | Remifentanil | |
| Molecular Weight | 376.4467 | |
| Molecular Formula | C20H28N2O5 | |
| CAS Number | 132875-61-7 | |
| SMILES | CCC(=O)N(C1=CC=CC=C1)C1(CCN(CCC(=O)OC)CC1)C(=O)OC | |
| External Links | ||
| DRUGBANK | DB00899 | |
| PubChem Compound | 60815 | |
| PDR | 1076 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 1.4 | - | 1.4 | - | DRUGBANK |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Factor | Reference |
|---|---|---|---|---|---|---|---|
| C Max | 20.0 | ng/ml | ~20 | ng/ml | intravenous injection, IV; | The Pharmacological Basis of Therapeutics | |
| Clearance | 2.4 | L/h/kg | 40.0 | ml/min/kg | normal,healthy; young; | DRUGBANK | Clearance | 3.0 | L/h/kg | 40-60 | ml/min/kg | normal,healthy; adults; patients; | Elderly ↓ ;Hepatic cirrhosis, cirr → ;RD, renal impairment, Renal disease，including uremia → ; | The Pharmacological Basis of Therapeutics | Clearance | 2.2 | L/h/kg | 37 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 0.35 | L/kg | 350.0 | ml/kg | DRUGBANK | Volume of Distribution | 0.45 | L/kg | 452±144 | ml/kg | Neonates; | DRUGBANK | Volume of Distribution | 0.22 | L/kg | 223±30.6 | ml/kg | Adolescents; | DRUGBANK | Volume of Distribution | 0.35 | L/kg | 0.3-0.4 | L/kg | normal,healthy; adults; patients; | Elderly ↓ ;Hepatic cirrhosis, cirr → ;RD, renal impairment, Renal disease，including uremia → ; | The Pharmacological Basis of Therapeutics | Volume of Distribution | 0.40 | L/kg | 0.4 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 0.18 | h | 1-20 | min | DRUGBANK | Half-life | 0.23 | h | 0.13-0.33 | h | RD, renal impairment, Renal disease，including uremia → ;Hepatic cirrhosis, cirr → ; | The Pharmacological Basis of Therapeutics | Half-life | 0.80 | h | 0.8 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Eliminate Route | 0 | % | ~0 | % | Urinary excretion; adults; Male, men; normal,healthy; surgery; human, homo sapiens; Unchanged drug; | The Pharmacological Basis of Therapeutics | |
| Protein Binding | 70.0 | % | 70 | % | plasma proteins; | DRUGBANK | Protein Binding | 92.0 | % | 92 | % | adults; Male, men; normal,healthy; surgery; human, homo sapiens; | The Pharmacological Basis of Therapeutics |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for neonates | 1.0 | mcg/kg/dose | 1 | mcg/kg/dose | intravenous injection, IV | Ultiva | remifentanil hydrochloride | PDR |
| Max dose for neonates | 1440.0 | mg/kg/day | 1 | mg/kg/minute | intravenous infusion, iv in drop | Ultiva | remifentanil hydrochloride | PDR |
| Max dose for neonates | 4.0 | mcg/kg/dose | 4 | mcg/kg/dose | intravenous injection, IV | Ultiva | remifentanil hydrochloride | PDR |
| Max dose for infants | 0.001 | mg/kg/dose | 1 | mcg/kg/dose | intravenous injection, IV | Ultiva | remifentanil hydrochloride | PDR |
| Max dose for infants | 1.872 | mg/kg/day | 1.3 | mg/kg/min | intravenous infusion, iv in drop | Ultiva | remifentanil hydrochloride | PDR |
| Max dose for infants | 0.004 | mg/kg/dose | 4 | mcg/kg/dose | intravenous injection, IV | Ultiva | remifentanil hydrochloride | PDR |
| Max dose for children | 0.001 | mg/kg/dose | 1 | mcg/kg/dose | intravenous injection, IV | Ultiva | remifentanil hydrochloride | PDR |
| Max dose for children | 1.3 | mg/kg/minute | 1.3 | mg/kg/minute | intravenous infusion, iv in drop | Ultiva | remifentanil hydrochloride | PDR |
| Max dose for children | 0.00125 | mg/kg/dose | 1.25 | mcg/kg/dose | intravenous injection, IV | Ultiva | remifentanil hydrochloride | PDR |
| Max dose for adolescents | 0.001 | mg/kg/dose | 1 | mcg/kg/dose | intravenous injection, IV | Ultiva | remifentanil hydrochloride | PDR |
| Max dose for adolescents | 2.88 | mg/kg/day | 2 | mcg/kg/minute | intravenous infusion, iv in drop | Ultiva | remifentanil hydrochloride | PDR |
| Max dose for geriatric | 1.0 | mcg/kg/dose | 1 | mcg/kg/dose | intravenous injection, IV | Ultiva | remifentanil hydrochloride | PDR |
| Max dose for geriatric | 2.88 | mg/kg/day | 2 | mcg/kg/minute | intravenous infusion, iv in drop | Ultiva | remifentanil hydrochloride | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1