DETAILS

Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID	DDPD00897
Drug Name	Triazolam
Molecular Weight	343.21
Molecular Formula	C17H12Cl2N4
CAS Number	28911-01-5
SMILES	CC1=NN=C2CN=C(C3=CC=CC=C3Cl)C3=C(C=CC(Cl)=C3)N12
External Links
	DRUGBANK	DB00897
	T3DB	T3D2564
	PubChem Compound	5556
	PDR	2361
	Drugs.com	Drugs.com Drug Page

Experimental Physicochemical Property

Property Name	Property Value	Unit	Raw Value	Raw Unit	Reference
Log P	2.42	-	2.42	-	BIOBYTE (1995)
Melting Point	234.0	℃	233-235	℃	DRUGBANK
Water Solubility	4.53	mg/L	4.53	mg/L	DRUGBANK
Log S	-4.08	-	-4.08	-	ADME Research, USCD

Pharmacokinetic/ Toxicokinetic Property

Property Name	Property Value	Unit	Raw Value	Raw Unit	Annotation	Reference
Bioavailability	44.0	%	44	%	PO, oral;	DRUGBANK
Clearance	0.18	L/h/kg	3	ml/min/kg	intravenous injection, IV; human, homo sapiens;	Human Intravenous Pharmacokinetic Dataset
Volume of Distribution	0.58	L/kg	0.58	L/kg	intravenous injection, IV; human, homo sapiens;	Human Intravenous Pharmacokinetic Dataset
Half-life	3.5	h	1.5-5.5	h		DRUGBANK
Half-life	2.7	h	2.7	h	intravenous injection, IV; human, homo sapiens;	Human Intravenous Pharmacokinetic Dataset
Toxicity LD50	1000.0	mg/kg	>1000	mg/kg	PO, oral; mouse;	T3DB
Toxicity LD50	5000.0	mg/kg	>5000	mg/kg	PO, oral; Rattus, Rat;	T3DB

Maximum Dosage

Property Name	Property Value	Unit	Raw Value	Raw Unit	Annotation	Brand Name	Component	Reference
Max dose for adults	0.5	mg/day	0.5	mg/day	PO, oral	Halcion	triazolam	PDR
Max dose for elderly	0.25	mg/day	0.25	mg/day	PO, oral	Halcion	triazolam	PDR

Drug Property Radar Chart

Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1