Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00889 ...
Drug Name Granisetron
Molecular Weight 312.417
Molecular Formula C18H24N4O
CAS Number 109889-09-0
SMILES CN1N=C(C(=O)N[C@@H]2C[C@@H]3CCC[C@H](C2)N3C)C2=C1C=CC=C2
External Links
DRUGBANK DB00889
PubChem Compound 5284566
PDR 1439
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 2.6 - 2.6 - DRUGBANK
Melting Point 219.0 ℃ 219 ℃ DRUGBANK

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
Absorption 100.0 % 100 % PO, oral; DRUGBANK
Bioavailability 60.0 % 60 % PO, oral; DRUGBANK
Bioavailability 60.0 % ~60 % PO, oral; The Pharmacological Basis of Therapeutics
C Max 6.0 ng/ml 6.0(0.6-31) ng/ml Oral single dose; tumor; The Pharmacological Basis of Therapeutics
C Max 64.0 ng/ml 64(18-176) ng/ml intravenous injection, IV; tumor; The Pharmacological Basis of Therapeutics
Clearance 0.52 L/h/kg 0.52 L/h/kg tumor; patients; DRUGBANK
Clearance 0.41 L/h/kg 0.41 L/h/kg Single dose; normal,healthy; DRUGBANK
Clearance 0.66 L/h/kg 11±9 ml/min/kg Elderly ↓ ;Hepatic cirrhosis, cirr ↓ ;RD, renal impairment, Renal disease，including uremia → ; The Pharmacological Basis of Therapeutics
Clearance 0.55 L/h/kg 9.1 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 3.0 L/kg 3.0±1.5 L/kg RD, renal impairment, Renal disease，including uremia → ; The Pharmacological Basis of Therapeutics
Volume of Distribution 3.7 L/kg 3.7 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 5.0 h 4-6 h normal,healthy; patients; DRUGBANK
Half-life 10.5 h 9-12 h tumor; patients; DRUGBANK
Half-life 5.3 h 5.3±3.5 h Hepatic cirrhosis, cirr ↑ ;RD, renal impairment, Renal disease，including uremia → ;Age ↑ ; The Pharmacological Basis of Therapeutics
Half-life 5.2 h 5.2 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Toxicity LD50 2000.0 mg/kg >2000 mg/kg PO, oral; Rattus, Rat; DRUGBANK
Eliminate Route 48.0 % 48 % Urinary excretion; DRUGBANK
Eliminate Route 38.0 % 38 % Faeces excretion; DRUGBANK
Eliminate Route 16.0 % 16±14 % Urinary excretion; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 65.0 % 65 % DRUGBANK
Protein Binding 65.0 % 65±9 % The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for children 0.01 mg/kg 10 mcg/kg intravenous injection, IV Granisetron Hydrochloride Tablets granisetron hydrochloride PDR
Max dose for children 0.04 mg/kg 40 mcg/kg intravenous injection, IV Granisetron Hydrochloride Tablets granisetron hydrochloride PDR
Max dose for children 0.04 mg/kg 40 mcg/kg PO, oral Granisetron Hydrochloride Tablets granisetron hydrochloride PDR
Max dose for adolescents 0.01 mg/day 10 mcg/kg intravenous injection, IV Granisetron Hydrochloride Tablets granisetron hydrochloride PDR
Max dose for adolescents 0.04 mg/day 40 mcg/kg intravenous injection, IV Granisetron Hydrochloride Tablets granisetron hydrochloride PDR
Max dose for adolescents 0.04 mg/day 40 mcg/kg PO, oral Granisetron Hydrochloride Tablets granisetron hydrochloride PDR
Max dose for adults 0.04 mg/kg 40 mcg/kg intravenous injection, IV Granisetron Hydrochloride Tablets granisetron hydrochloride PDR
Max dose for adults 2.0 mg 2 mg PO, oral Granisetron Hydrochloride Tablets granisetron hydrochloride PDR
Max dose for adults 1.0 patch 1 patch skin/dermal Granisetron Hydrochloride Tablets granisetron hydrochloride PDR
Max dose for adults 10.0 mg 10 mg subcutaneous injection, SC Granisetron Hydrochloride Tablets granisetron hydrochloride PDR
Max dose for geriatric 40.0 mcg/kg 40 mcg/kg intravenous injection, IV Granisetron Hydrochloride Tablets granisetron hydrochloride PDR
Max dose for geriatric 2.0 mg 2 mg PO, oral Granisetron Hydrochloride Tablets granisetron hydrochloride PDR
Max dose for geriatric 1.0 patch 1 patch skin/dermal Granisetron Hydrochloride Tablets granisetron hydrochloride PDR
Max dose for geriatric 10.0 mg 10 mg subcutaneous injection, SC Granisetron Hydrochloride Tablets granisetron hydrochloride PDR
Max dose for children 0.01 mg/kg 10 mcg/kg intravenous injection, IV Granisetron Hydrochloride Injection 1 mg/mL and 0.1 mg/mL granisetron hydrochloride PDR
Max dose for children 0.04 mg/kg 40 mcg/kg intravenous injection, IV Granisetron Hydrochloride Injection 1 mg/mL and 0.1 mg/mL granisetron hydrochloride PDR
Max dose for children 0.04 mg/kg 40 mcg/kg PO, oral Granisetron Hydrochloride Injection 1 mg/mL and 0.1 mg/mL granisetron hydrochloride PDR
Max dose for adolescents 0.01 mg/day 10 mcg/kg intravenous injection, IV Granisetron Hydrochloride Injection 1 mg/mL and 0.1 mg/mL granisetron hydrochloride PDR
Max dose for adolescents 0.04 mg/day 40 mcg/kg intravenous injection, IV Granisetron Hydrochloride Injection 1 mg/mL and 0.1 mg/mL granisetron hydrochloride PDR
Max dose for adolescents 0.04 mg/day 40 mcg/kg PO, oral Granisetron Hydrochloride Injection 1 mg/mL and 0.1 mg/mL granisetron hydrochloride PDR
Max dose for adults 0.04 mg/kg 40 mcg/kg intravenous injection, IV Granisetron Hydrochloride Injection 1 mg/mL and 0.1 mg/mL granisetron hydrochloride PDR
Max dose for adults 2.0 mg 2 mg PO, oral Granisetron Hydrochloride Injection 1 mg/mL and 0.1 mg/mL granisetron hydrochloride PDR
Max dose for adults 1.0 patch 1 patch skin/dermal Granisetron Hydrochloride Injection 1 mg/mL and 0.1 mg/mL granisetron hydrochloride PDR
Max dose for adults 10.0 mg 10 mg subcutaneous injection, SC Granisetron Hydrochloride Injection 1 mg/mL and 0.1 mg/mL granisetron hydrochloride PDR
Max dose for geriatric 40.0 mcg/kg 40 mcg/kg intravenous injection, IV Granisetron Hydrochloride Injection 1 mg/mL and 0.1 mg/mL granisetron hydrochloride PDR
Max dose for geriatric 2.0 mg 2 mg PO, oral Granisetron Hydrochloride Injection 1 mg/mL and 0.1 mg/mL granisetron hydrochloride PDR
Max dose for geriatric 1.0 patch 1 patch skin/dermal Granisetron Hydrochloride Injection 1 mg/mL and 0.1 mg/mL granisetron hydrochloride PDR
Max dose for geriatric 10.0 mg 10 mg subcutaneous injection, SC Granisetron Hydrochloride Injection 1 mg/mL and 0.1 mg/mL granisetron hydrochloride PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1