Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00888 ...
Drug Name Mechlorethamine
Molecular Weight 156.054
Molecular Formula C5H11Cl2N
CAS Number 51-75-2
SMILES CN(CCCl)CCCl
External Links
DRUGBANK DB00888
T3DB T3D4204
PubChem Compound 4033
PDR 2031
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 0.91 - 0.91 - SELASSIE,CD ET AL. (1990)
Boiling Point 87.0 ℃ 87 ℃ PhysProp
Melting Point 109.0 ℃ 108-110 ℃ MSDS
pKa 6.43 - 6.43 - PERRIN,DD (1965)

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
Half-life 0.25 h 15 min DRUGBANK
Toxicity LD50 10.0 mg/kg 10.0 mg/kg PO, oral; Rattus, Rat; DRUGBANK
Toxicity LD50 10.0 mg/kg 10.0 mg/kg PO, oral; Rattus, Rat; T3DB

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for children 6.0 mg/m2/dose 6 mg/m2/dose intravenous injection, IV Mustargen mechlorethamine hydrochloride PDR
Max dose for adolescents 6.0 mg/m2/dose 6 mg/m2/dose intravenous injection, IV Mustargen mechlorethamine hydrochloride PDR
Max dose for adults 0.4 mg/kg/dose 0.4 mg/kg/dose intravenous injection, IV Mustargen mechlorethamine hydrochloride PDR
Max dose for adults 6.0 mg/m2/dose 6 mg/m2/dose intravenous injection, IV Mustargen mechlorethamine hydrochloride PDR
Max dose for adults 0.4 mg/kg/dose 0.4 mg/kg/dose Intracavitary Mustargen mechlorethamine hydrochloride PDR
Max dose for adults 1.0 appLication/day 1 appLication/day gel Mustargen mechlorethamine hydrochloride PDR
Max dose for geriatric 0.4 mg/kg/dose 0.4 mg/kg/dose intravenous injection, IV Mustargen mechlorethamine hydrochloride PDR
Max dose for geriatric 6.0 mg/m2/dose 6 mg/m2/dose intravenous injection, IV Mustargen mechlorethamine hydrochloride PDR
Max dose for geriatric 0.4 mg/kg/dose 0.4 mg/kg/dose Intracavitary Mustargen mechlorethamine hydrochloride PDR
Max dose for geriatric 1.0 application/day 1 application/day gel Mustargen mechlorethamine hydrochloride PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1