Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00883 ...
Drug Name Isosorbide dinitrate
Molecular Weight 236.1363
Molecular Formula C6H8N2O8
CAS Number 87-33-2
SMILES [H][C@]12OC[C@H](O[N+]([O-])=O)[C@@]1([H])OC[C@H]2O[N+]([O-])=O
External Links
DRUGBANK DB00883
PubChem Compound 6883
PDR 2148
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 1.31 - 1.31 - HANSCH,C ET AL. (1995)
Melting Point 70.0 ℃ 70 ℃ PhysProp
Water Solubility 550.0 mg/L 550 mg/L YALKOWSKY,SH & DANNENFELSER,RM 1992)
Log S -2.63 - -2.63 - ADME Research, USCD

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
Absorption 100.0 % ~100 % PO, oral; DRUGBANK
Bioavailability 25.0 % 25(10-90) % PO, oral; DRUGBANK
Bioavailability 22.0 % 22±14 % PO, oral; The Pharmacological Basis of Therapeutics
Bioavailability 45.0 % 45±16 % sublingual; The Pharmacological Basis of Therapeutics
Bioavailability 33.0 % 33±17 % skin/dermal; The Pharmacological Basis of Therapeutics
C Max 9.9 ng/ml 42(59-166) nM PO, oral; immediate release formulation; The Pharmacological Basis of Therapeutics
C Max 48.9 ng/ml 207(197-335) nM PO, oral; Active metabolite; immediate release formulation; The Pharmacological Basis of Therapeutics
C Max 212.5 ng/ml 900(790-1080) nM PO, oral; Active metabolite; immediate release formulation; The Pharmacological Basis of Therapeutics
C Max 0 ng/ml ~0 nM PO, oral; Sustained Release formulation; The Pharmacological Basis of Therapeutics
C Max 6.6 ng/ml 28(23-33) nM PO, oral; Active metabolite; Sustained Release formulation; The Pharmacological Basis of Therapeutics
C Max 41.3 ng/ml 175(154-267) nM PO, oral; Active metabolite; Sustained Release formulation; The Pharmacological Basis of Therapeutics
T Max 0.30 h 0.3(0.2-0.5) h PO, oral; immediate release formulation; The Pharmacological Basis of Therapeutics
T Max 0.60 h 0.6(0.2-1.6) h PO, oral; Active metabolite; immediate release formulation; The Pharmacological Basis of Therapeutics
T Max 0.70 h 0.7(0.3-1.9) h PO, oral; Active metabolite; immediate release formulation; The Pharmacological Basis of Therapeutics
T Max 0 h ~0 h PO, oral; Sustained Release formulation; The Pharmacological Basis of Therapeutics
T Max 2.8 h 2.8(2.7-3.7) h PO, oral; Active metabolite; Sustained Release formulation; The Pharmacological Basis of Therapeutics
T Max 5.1 h 5.1(4.2-6.6) h PO, oral; Active metabolite; Sustained Release formulation; The Pharmacological Basis of Therapeutics
Clearance 2.8 L/h/kg 46(38-59) ml/min/kg normal,healthy; adults;  Female, women → ;Hepatic cirrhosis, cirr ↓ ;RD, renal impairment, Renal disease，including uremia → ;congestive heart disease → ;Somking → ; The Pharmacological Basis of Therapeutics
Clearance 1.9 L/h/kg 31 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 3.0 L/kg 2.0-4 L/kg DRUGBANK
Volume of Distribution 3.1 L/kg 3.1(2.2-8.6) L/kg normal,healthy; adults; The Pharmacological Basis of Therapeutics
Volume of Distribution 1.9 L/kg 1.9 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 1.0 h 1 h DRUGBANK
Half-life 0.70 h 0.7(0.6-2.0) h  Female, women → ;RD, renal impairment, Renal disease，including uremia → ; The Pharmacological Basis of Therapeutics
Half-life 1.7 h 1.7 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Eliminate Route 1.0 % <1 % Urinary excretion; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 28.0 % 28±12 % The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for adults 480.0 mg/day 480 mg/day PO, oral Isordil Oral Titradose isosorbide dinitrate PDR
Max dose for adults 160.0 mg/day 160 mg/day PO, oral Isordil Oral Titradose isosorbide dinitrate PDR
Max dose for elderly 480.0 mg/day 480 mg/day PO, oral Isordil Oral Titradose isosorbide dinitrate PDR
Max dose for elderly 160.0 mg/day 160 mg/day PO, oral Isordil Oral Titradose isosorbide dinitrate PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1