Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00881 ...
Drug Name Quinapril
Molecular Weight 438.5161
Molecular Formula C25H30N2O5
CAS Number 85441-61-8
SMILES CCOC(=O)[C@H](CCC1=CC=CC=C1)N[C@@H](C)C(=O)N1CC2=CC=CC=C2C[C@H]1C(O)=O
External Links
DRUGBANK DB00881
T3DB T3D4733
PubChem Compound 54892
PDR 2551
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 0.86 - 0.86 - Pfizer Canada Monograph
Melting Point 125.0 ℃ 120-130 ℃ Chemspider
pKa 2.8 - 2.8 - Pfizer Canada Monograph

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
AUC 2443.0 ng.h/ml 2443.0 ng.h/ml PO, oral; Male, men; normal,healthy; DRUGBANK
Bioavailability 65.0 % 50-80 % PO, oral; DRUGBANK
Bioavailability 47.5 % 35-60 % PO, oral; high-fat meal; high-fat meal ↓ ; DRUGBANK
Bioavailability 52.0 % 52±15 % PO, oral; The Pharmacological Basis of Therapeutics
C Max 1526.0 ng/ml 1526.0 ng/ml PO, oral; Male, men; normal,healthy; DRUGBANK
C Max 923.0 ng/ml 923±277 ng/ml intravenous injection, IV; Drug form; The Pharmacological Basis of Therapeutics
C Max 207.0 ng/ml 207±89 ng/ml PO, oral; The Pharmacological Basis of Therapeutics
T Max 1.0 h <1 h PO, oral; DRUGBANK
T Max 2.5 h 2.5 h DRUGBANK
T Max 2.3 h 2.3±0.9 h intravenous injection, IV; Drug form; The Pharmacological Basis of Therapeutics
T Max 1.4 h 1.4±0.8 h PO, oral; The Pharmacological Basis of Therapeutics
Clearance 4.1 L/h 68.0 ml/min DRUGBANK
Clearance 0.0588 L/h/kg 0.98±0.22 ml/min/kg intravenous injection, IV; RD, renal impairment, Renal disease，including uremia ↓ ; The Pharmacological Basis of Therapeutics
Volume of Distribution 13.9 L 13.9 L Average volume of distribution; DRUGBANK
Volume of Distribution 0.19 L/kg 0.19±0.04 L/kg intravenous injection, IV; The Pharmacological Basis of Therapeutics
Half-life 2.3 h 2.3 h elimination half-life; DRUGBANK
Half-life 0.85 h 0.8-0.9 h PO, oral; RD, renal impairment, Renal disease，including uremia ↑ ; The Pharmacological Basis of Therapeutics
Half-life 2.5 h 2.1-2.9 h intravenous injection, IV; RD, renal impairment, Renal disease，including uremia ↑ ; The Pharmacological Basis of Therapeutics
Toxicity LD50 3541.0 mg/kg 3541.0 mg/kg PO, oral; Rattus, Rat; DRUGBANK
Toxicity LD50 1739.0 mg/kg 1739.0 mg/kg PO, oral; mouse; DRUGBANK
Toxicity LD50 1739.0 mg/kg 1739.0 mg/kg PO, oral; mouse; T3DB
Eliminate Route 96.0 % 96 % Urinary excretion; DRUGBANK
Eliminate Route 3.1 % 3.1±1.2 % Urinary excretion; PO, oral; Unchanged drug; The Pharmacological Basis of Therapeutics
Eliminate Route 96.0 % 96 % Urinary excretion; intravenous injection, IV; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 97.0 % 97 % The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for adults 80.0 mg/day 80 mg/day PO, oral Accupril quinapril hydrochloride PDR
Max dose for adults 40.0 mg/day 40 mg/day PO, oral Accupril quinapril hydrochloride PDR
Max dose for elderly 80.0 mg/day 80 mg/day PO, oral Accupril quinapril hydrochloride PDR
Max dose for elderly 40.0 mg/day 40 mg/day PO, oral Accupril quinapril hydrochloride PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1