Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00877 ...
Drug Name Sirolimus
Molecular Weight 914.187
Molecular Formula C51H79NO13
CAS Number 53123-88-9
SMILES [H][C@@]1(C[C@@H](C)[C@]2([H])CC(=O)[C@H](C)\C=C(C)\[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)\C=C\C=C\C=C(C)\[C@H](C[C@]3([H])CC[C@@H](C)[C@@](O)(O3)C(=O)C(=O)N3CCCC[C@@]3([H])C(=O)O2)OC)CC[C@@H](O)[C@@H](C1)OC
External Links
DRUGBANK DB00877
T3DB T3D2921
PubChem Compound 5284616
PDR 2097
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 4.3 - 4.3 - DRUGBANK

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
Bioavailability 15.0 % ~15 % PO, oral; The Pharmacological Basis of Therapeutics
C Max 67.0 ng/ml 67±23 ng/ml Oral single dose; normal,healthy; The Pharmacological Basis of Therapeutics
C Max 152.0 ng/ml 94-210 ng/ml Oral multiple dose; renal transplant; The Pharmacological Basis of Therapeutics
T Max 0.81 h 0.81±0.17 h Oral single dose; normal,healthy; The Pharmacological Basis of Therapeutics
T Max 1.4 h 1.4±1.2 h Oral multiple dose; renal transplant; The Pharmacological Basis of Therapeutics
Clearance 0.21 L/h/kg 3.47±1.58 ml/min/kg apparent clearance; renal transplant; Male, men;  Female, women; patients; The Pharmacological Basis of Therapeutics
Volume of Distribution 12.0 L/kg 12±4.6 L/kg Apparent volume of distribution; renal transplant; Male, men;  Female, women; patients; The Pharmacological Basis of Therapeutics
Half-life 60.0 h 57-63 h DRUGBANK
Half-life 62.3 h 62.3±16.2 h PO, oral; The Pharmacological Basis of Therapeutics
Toxicity LD50 800.0 mg/kg >800 mg/kg PO, oral; Rattus, Rat; T3DB
Toxicity LD50 800.0 mg/kg >800 mg/kg PO, oral; mouse; T3DB
Protein Binding 92.0 % 92 % DRUGBANK
Protein Binding 40.0 % 40 % renal transplant; human, homo sapiens; The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for adolescents 40.0 mg/day 40 mg/day PO, oral Rapamune sirolimus PDR
Max dose for adults 40.0 mg/day 40 mg/day PO, oral Rapamune sirolimus PDR
Max dose for geriatric 40.0 mg/day 40 mg/day PO, oral Rapamune sirolimus PDR

Drug Property Radar Chart

...

Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1