Drug ID | DDPD00877 |
|
Drug Name | Sirolimus | |
Molecular Weight | 914.187 | |
Molecular Formula | C51H79NO13 | |
CAS Number | 53123-88-9 | |
SMILES | [H][C@@]1(C[C@@H](C)[C@]2([H])CC(=O)[C@H](C)\C=C(C)\[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)\C=C\C=C\C=C(C)\[C@H](C[C@]3([H])CC[C@@H](C)[C@@](O)(O3)C(=O)C(=O)N3CCCC[C@@]3([H])C(=O)O2)OC)CC[C@@H](O)[C@@H](C1)OC | |
External Links | ||
DRUGBANK | DB00877 | |
T3DB | T3D2921 | |
PubChem Compound | 5284616 | |
PDR | 2097 | |
Drugs.com | Drugs.com Drug Page |
Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
---|---|---|---|---|---|
Log P | 4.3 | - | 4.3 | - | DRUGBANK |
Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
---|---|---|---|---|---|---|
Bioavailability | 15.0 | % | ~15 | % | PO, oral; | The Pharmacological Basis of Therapeutics |
C Max | 67.0 | ng/ml | 67±23 | ng/ml | Oral single dose; normal,healthy; | The Pharmacological Basis of Therapeutics |
C Max | 152.0 | ng/ml | 94-210 | ng/ml | Oral multiple dose; renal transplant; | The Pharmacological Basis of Therapeutics |
T Max | 0.81 | h | 0.81±0.17 | h | Oral single dose; normal,healthy; | The Pharmacological Basis of Therapeutics |
T Max | 1.4 | h | 1.4±1.2 | h | Oral multiple dose; renal transplant; | The Pharmacological Basis of Therapeutics |
Clearance | 0.21 | L/h/kg | 3.47±1.58 | ml/min/kg | apparent clearance; renal transplant; Male, men; Female, women; patients; | The Pharmacological Basis of Therapeutics |
Volume of Distribution | 12.0 | L/kg | 12±4.6 | L/kg | Apparent volume of distribution; renal transplant; Male, men; Female, women; patients; | The Pharmacological Basis of Therapeutics |
Half-life | 60.0 | h | 57-63 | h | DRUGBANK | |
Half-life | 62.3 | h | 62.3±16.2 | h | PO, oral; | The Pharmacological Basis of Therapeutics |
Toxicity LD50 | 800.0 | mg/kg | >800 | mg/kg | PO, oral; Rattus, Rat; | T3DB |
Toxicity LD50 | 800.0 | mg/kg | >800 | mg/kg | PO, oral; mouse; | T3DB |
Protein Binding | 92.0 | % | 92 | % | DRUGBANK | |
Protein Binding | 40.0 | % | 40 | % | renal transplant; human, homo sapiens; | The Pharmacological Basis of Therapeutics |
Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
---|---|---|---|---|---|---|---|---|
Max dose for adolescents | 40.0 | mg/day | 40 | mg/day | PO, oral | Rapamune | sirolimus | PDR |
Max dose for adults | 40.0 | mg/day | 40 | mg/day | PO, oral | Rapamune | sirolimus | PDR |
Max dose for geriatric | 40.0 | mg/day | 40 | mg/day | PO, oral | Rapamune | sirolimus | PDR |