Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00875 ...
Drug Name Flupentixol
Molecular Weight 434.52
Molecular Formula C23H25F3N2OS
CAS Number 2709-56-0
SMILES [H]\C(CCN1CCN(CCO)CC1)=C1/C2=CC=CC=C2SC2=C1C=C(C=C2)C(F)(F)F
External Links
DRUGBANK DB00875
T3DB T3D2920
PubChem Compound 5281881
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 4.51 - 4.51 - HANSCH,C ET AL. (1995)
Water Solubility 0.346 mg/L 0.000346 mg/ml DRUGBANK

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
Clearance 0.25 L/h/kg 4.14 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 29.0 h 19-39 h DRUGBANK
Half-life 34.2 h 34.2 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Toxicity LD50 300.0 mg/kg 300.0 mg/kg PO, oral; mouse; DRUGBANK
Toxicity LD50 791.0 mg/kg 791.0 mg/kg PO, oral; Rattus, Rat; DRUGBANK
Toxicity LD50 87.0 mg/kg 87.0 mg/kg intravenous injection, IV; mouse; DRUGBANK
Toxicity LD50 37.0 mg/kg 37.0 mg/kg intravenous injection, IV; Rattus, Rat; DRUGBANK
Toxicity LD50 300.0 mg/kg 300.0 mg/kg PO, oral; mouse; T3DB
Toxicity LD50 791.0 mg/kg 791.0 mg/kg PO, oral; Rattus, Rat; T3DB
Toxicity LD50 87.0 mg/kg 87.0 mg/kg intravenous injection, IV; mouse; T3DB
Toxicity LD50 37.0 mg/kg 37.0 mg/kg intravenous injection, IV; Rattus, Rat; T3DB
Protein Binding 95.0 % >95 % plasma proteins; DRUGBANK

Maximum Dosage

Not Available

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1