Basic Information
| Drug ID | DDPD00874 |
|
| Drug Name | Guaifenesin | |
| Molecular Weight | 198.2158 | |
| Molecular Formula | C10H14O4 | |
| CAS Number | 93-14-1 | |
| SMILES | COC1=CC=CC=C1OCC(O)CO | |
| External Links | ||
| DRUGBANK | DB00874 | |
| T3DB | T3D4556 | |
| PubChem Compound | 3516 | |
| PDR | 1275 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 1.39 | - | 1.39 | - | SMITH,JT & VINJAMOORI,DT (1995) |
| Boiling Point | 215.0 | ℃ | 215 | ℃ | PhysProp |
| Melting Point | 78.75 | ℃ | 78.5-79 | ℃ | British Patent 628,497. |
| Water Solubility | 50000.0 | mg/L | 50000 | mg/L | MERCK INDEX 1996) |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Clearance | 94.8 | L/h | 94.8 | L/h | Average clearance; | DRUGBANK |
| Half-life | 1.0 | h | ~1 | h | DRUGBANK | |
| Toxicity LD50 | 1510.0 | mg/kg | 1510.0 | mg/kg | PO, oral; Rattus, Rat; | DRUGBANK | Toxicity LD50 | 1510.0 | mg/kg | 1510.0 | mg/kg | PO, oral; Rattus, Rat; | T3DB |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for children | 2400.0 | mg/day | 2400 | mg/day | PO, oral | Mucinex | guaifenesin | PDR |
| Max dose for children | 1200.0 | mg/day | 1200 | mg/day | PO, oral | Mucinex | guaifenesin | PDR |
| Max dose for children | 600.0 | mg/day | 600 | mg/day | PO, oral | Mucinex | guaifenesin | PDR |
| Max dose for adolescents | 2400.0 | mg/day | 2400 | mg/day | PO, oral | Mucinex | guaifenesin | PDR |
| Max dose for adults | 2400.0 | mg/day | 2400 | mg/day | PO, oral | Mucinex | guaifenesin | PDR |
| Max dose for geriatric | 2400.0 | mg/day | 2400 | mg/day | PO, oral | Mucinex | guaifenesin | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1