Basic Information
| Drug ID | DDPD00872 |
|
| Drug Name | Conivaptan | |
| Molecular Weight | 498.5744 | |
| Molecular Formula | C32H26N4O2 | |
| CAS Number | 210101-16-9 | |
| SMILES | CC1=NC2=C(CCN(C(=O)C3=CC=C(NC(=O)C4=CC=CC=C4C4=CC=CC=C4)C=C3)C3=CC=CC=C23)N1 | |
| External Links | ||
| DRUGBANK | DB00872 | |
| PubChem Compound | 151171 | |
| PDR | 2107 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 6.3 | - | 6.3 | - | DRUGBANK |
| Water Solubility | 150.0 | mg/L | 0.15 | mg/ml | DRUGBANK |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Clearance | 0.18 | L/h/kg | 3 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 0.76 | L/kg | 0.76 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 5.0 | h | 5 | h | DRUGBANK | Half-life | 6.7 | h | 6.7 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Protein Binding | 99.0 | % | 99 | % | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for adults | 20.0 | mg/dose | 20 | mg/dose | intravenous injection, IV | Vaprisol | conivaptan hydrochloride | PDR |
| Max dose for adults | 40.0 | mg/day | 40 | mg/day | intravenous infusion, iv in drop | Vaprisol | conivaptan hydrochloride | PDR |
| Max dose for elderly | 20.0 | mg/dose | 20 | mg/dose | intravenous injection, IV | Vaprisol | conivaptan hydrochloride | PDR |
| Max dose for elderly | 40.0 | mg/day | 40 | mg/day | intravenous infusion, iv in drop | Vaprisol | conivaptan hydrochloride | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1