| Property Name |
Property Value |
Unit |
Raw Value |
Raw Unit |
Annotation |
Reference |
| Absorption |
40.0 |
% |
30-50 |
% |
PO, oral; |
DRUGBANK |
| Clearance |
18.7 |
L/h |
311±112 |
ml/min |
|
DRUGBANK |
Clearance |
0.20 |
L/h/kg |
3.4 |
ml/min/kg |
intravenous injection, IV; human, homo sapiens; |
Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution |
1.5 |
L/kg |
1.5 |
L/kg |
intravenous injection, IV; human, homo sapiens; |
Human Intravenous Pharmacokinetic Dataset |
| Half-life |
5.7 |
h |
5.5-5.9 |
h |
|
DRUGBANK |
Half-life |
15.0 |
h |
15 |
h |
intravenous injection, IV; human, homo sapiens; |
Human Intravenous Pharmacokinetic Dataset |
| Toxicity LD50 |
8700.0 |
mg/kg |
8.7 |
g/kg |
PO, oral; Rattus, Rat; |
DRUGBANK |
Toxicity LD50 |
205.0 |
mg/kg |
205.0 |
mg/kg |
PO, oral; mouse; |
DRUGBANK |
Toxicity LD50 |
1500.0 |
mg/kg |
1.5 |
g/kg |
PO, oral; dog; |
DRUGBANK |
Toxicity LD50 |
220.0 |
mg/kg |
220.0 |
mg/kg |
Intraperitoneal, IP; Rattus, Rat; |
DRUGBANK |
Toxicity LD50 |
130.0 |
mg/kg |
130.0 |
mg/kg |
Intraperitoneal, IP; mouse; |
DRUGBANK |
Toxicity LD50 |
8000.0 |
mg/kg |
>8 |
g/kg |
PO, oral; rabbit; |
DRUGBANK |
Toxicity LD50 |
36.0 |
mg/kg |
36.0 |
mg/kg |
intravenous injection, IV; mouse; |
DRUGBANK |
Toxicity LD50 |
116.0 |
mg/kg |
116.0 |
mg/kg |
intravenous injection, IV; dog; |
DRUGBANK |
Toxicity LD50 |
110.0 |
mg/kg |
110.0 |
mg/kg |
intravenous injection, IV; rabbit; |
DRUGBANK |
| Eliminate Route |
90.0 |
% |
~90 |
% |
Urinary excretion; subcutaneous injection, SC; |
DRUGBANK |
Eliminate Route |
54.0 |
% |
~54 |
% |
Urinary excretion; Unchanged drug; |
DRUGBANK |
