Basic Information
| Drug ID | DDPD00869 |
|
| Drug Name | Dorzolamide | |
| Molecular Weight | 324.44 | |
| Molecular Formula | C10H16N2O4S3 | |
| CAS Number | 120279-96-1 | |
| SMILES | CCN[C@H]1C[C@H](C)S(=O)(=O)C2=C1C=C(S2)S(N)(=O)=O | |
| External Links | ||
| DRUGBANK | DB00869 | |
| PubChem Compound | 5284549 | |
| PDR | 395 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Melting Point | 264.0 | ℃ | 264 | ℃ | FDA Label |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| T Max | 1344.0 | h | 8 | week | PO, oral; | DRUGBANK | T Max | 1344.0 | h | 8 | week | skin/dermal; | DRUGBANK |
| Half-life | 2880.0 | h | >=120 | day | elimination half-life; | DRUGBANK | Half-life | 2880.0 | h | ~4 | month | elimination half-life; | DRUGBANK |
| Toxicity LD50 | 1927.0 | mg/kg | 1927.0 | mg/kg | PO, oral; Rattus, Rat; | DRUGBANK | Toxicity LD50 | 1320.0 | mg/kg | 1320.0 | mg/kg | PO, oral; mouse; | DRUGBANK | Toxicity LD50 | 2000.0 | mg/kg | >2 | g/kg | subcutaneous injection, SC; mouse; Rattus, Rat; | DRUGBANK |
| Protein Binding | 33.0 | % | ~33 | % | plasma proteins; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for children | 3.0 | drop/day | 3 | drop/day | ophthalmic administration | Trusopt | dorzolamide hydrochloride | PDR |
| Max dose for adolescents | 3.0 | drop/day | 3 | drop/day | ophthalmic administration | Trusopt | dorzolamide hydrochloride | PDR |
| Max dose for adults | 3.0 | drop/day | 3 | drop/day | ophthalmic administration | Trusopt | dorzolamide hydrochloride | PDR |
| Max dose for elderly | 3.0 | drop/day | 3 | drop/day | ophthalmic administration | Trusopt | dorzolamide hydrochloride | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1