Basic Information
| Drug ID | DDPD00859 |
|
| Drug Name | Penicillamine | |
| Molecular Weight | 149.211 | |
| Molecular Formula | C5H11NO2S | |
| CAS Number | 52-67-5 | |
| SMILES | [H][C@](N)(C(O)=O)C(C)(C)S | |
| External Links | ||
| DRUGBANK | DB00859 | |
| PubChem Compound | 5852 | |
| PDR | 848 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | -1.78 | - | -1.78 | - | HANSCH,C ET AL. (1995) |
| Melting Point | 198.5 | ℃ | 198.5 | ℃ | PhysProp |
| Water Solubility | 111000.0 | mg/L | 111000 | mg/L | YALKOWSKY,SH & DANNENFELSER,RM 1992) |
| pKa | 1.8 | - | 1.8 | - | MERCK for CO; NH2-7.9; thiol-10.5 |
| Log S | -0.13 | - | -0.13 | - | ADME Research, USCD |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Clearance | 0.64 | L/h/kg | 10.65 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 1.3 | L/kg | 1.26 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 1.0 | h | 1 | h | DRUGBANK | Half-life | 3.0 | h | 3.04 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Toxicity TDLo | 5.0 | mg/kg/day | 210.0 | mg/kg/6W | Female, women; | DRUGBANK |
| Protein Binding | 80.0 | % | >80 | % | plasma proteins; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for children | 1000.0 | mg/day | 1 | g/day | PO, oral | Depen | penicillamine | PDR |
| Max dose for children | 1500.0 | mg/day | 1.5 | g/day | PO, oral | Depen | penicillamine | PDR |
| Max dose for children | 4000.0 | mg/day | 4 | g/day | PO, oral | Depen | penicillamine | PDR |
| Max dose for children | 10.0 | mg/kg/day | 10 | mg/kg/day | PO, oral | Depen | penicillamine | PDR |
| Max dose for adolescents | 1000.0 | mg/day | 1 | g/day | PO, oral | Depen | penicillamine | PDR |
| Max dose for adolescents | 1500.0 | mg/day | 1.5 | g/day | PO, oral | Depen | penicillamine | PDR |
| Max dose for adolescents | 4000.0 | mg/day | 4 | g/day | PO, oral | Depen | penicillamine | PDR |
| Max dose for adolescents | 10.0 | mg/kg/day | 10 | mg/kg/day | PO, oral | Depen | penicillamine | PDR |
| Max dose for adults | 2000.0 | mg/day | 2 | g/day | PO, oral | Depen | penicillamine | PDR |
| Max dose for adults | 1500.0 | mg/day | 1.5 | g/day | PO, oral | Depen | penicillamine | PDR |
| Max dose for adults | 1000.0 | mg/day | 1 | g/day | PO, oral | Depen | penicillamine | PDR |
| Max dose for adults | 5000.0 | mg/day | 5 | g/day | PO, oral | Depen | penicillamine | PDR |
| Max dose for adults | 250.0 | mg/day | 250 | mg/day | Depen | penicillamine | PDR | |
| Max dose for adults | 625.0 | mg/day | 625 | mg/day | PO, oral | Depen | penicillamine | PDR |
| Max dose for elderly | 2000.0 | mg/day | 2 | g/day | PO, oral | Depen | penicillamine | PDR |
| Max dose for elderly | 1500.0 | mg/day | 1.5 | g/day | PO, oral | Depen | penicillamine | PDR |
| Max dose for elderly | 1000.0 | mg/day | 1 | g/day | PO, oral | Depen | penicillamine | PDR |
| Max dose for elderly | 5000.0 | mg/day | 5 | g/day | PO, oral | Depen | penicillamine | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1